Abstract: Abstract：Non-resolving inflammation may initiate cancerazation and is involved in cancer occurrence， development， metastasis， drug resistance and various pathological processes. Previous Studies suggested that critical network nodes in regulation of carcinogenesis were closely associated with signaling pathways related to stimulation， immunization， stress and inflammation. Particularly，NF-κB pathway in non-resolving inflammation and cancer metastasis plays a key regulatory role in carcinogenesis. In carcinogenesis of oral mucosa， upstream regulatory networks of miRNAs play a critical role. Using the non-resolving (chronic) inflammation malignant transformation models， such as oral lichen planus and multiple-step carcinogenesis models， it will establish malignant transformation spatiotemporal nodes and miRNA or mRNA expression patterns related to the processes of carcinogenesis， promoting and development. It will also investigate the dynamic relationship between non-resolving inflammation and oral cancer through the comprehensive utilization of medical statistics， biological informatics analysis and the integration analysis on epigenetics and genetics levels. No doubt， to determine the basic regulatory network of malignant transformation nodes and key factors of carcinogenesis， the novel cancer treatment model， "anti-inflammatory"， will provide rationale and effective interventions targeting in the future.

Key words: non-resolving inflammation, oral cancer, carcinogenesis, regulatory network node

摘要： 摘要：非可控性炎症可能启动并参与了癌症的发生、发展、浸润转移和抵抗治疗等各个病理过程。研究表明，癌变过程中调控网络的关键节点多与应激、炎症和免疫相关。炎症相关信号通路，尤其是NF-κB通路，在慢性炎症癌变和转移中发挥关键调控作用。在口腔黏膜癌变过程中，上游miRNA基因调控网络发挥了十分关键的作用。以非可控性炎症恶性转化疾病模型—口腔扁平苔藓和口腔黏膜体外多步骤癌变模型为研究对象，针对癌启动、促进和发展过程，确立恶性转化时空调控节点的miRNA 和mRNA表达谱型，综合利用医学统计和生物信息学分析技术及整合分析策略，在遗传学和表观遗传学2个层面，动态解析非可控性炎症和癌症之间存在的必然联系，确定恶性转变节点的基本调控网络和癌变的关键因子，无疑能为 “抗炎”这一新型癌症治疗模式提供理论依据和有效干预靶点。

关键词: 非可控炎症, 口腔癌, 癌变, 调控节点