Abstract: To evaluate the efficacy and safety of total glucosides of paeony combined with intralesional triamcinolone acetonide injection for oral lichen planus（OLP）. Methods    Totally 58 patients with clinically confirmed erosive and ulcerative OLP were randomly divided into two groups，treated with total glucosides of paeony+triamcinolone acetonide and triamcinolone acetonide respectively；meanwhile，the VAS and REU scoring system was utilized to compare the signs and symptoms. Results    The effectiveness rate of the treatment group was 82.8%（24/29），the control group 79.3%（23/29），showing that there was no statistical significance of effectiveness rate between them（χ2 = 0.112，P > 0.05）at the first month. The effectiveness rate of the treatment group was 86.2%（25/29），the control group 51.7%（15/29），showing that there was statistical significance of effectiveness rate between them（χ2 = 15.241，P < 0.01）at the third month. Conclusion    Total glucosides of paeony combined with intralesional triamcinolone acetonide injection is effective and safe in the treatment of OLP.

Key words: total glucosides of paeony, triamcinolone acetonide, oral lichen planus

摘要： 目的    评价白芍总苷联合曲安奈德局部注射治疗口腔扁平苔藓（OLP）的临床疗效。方法    选择2010年8月至2011年8月就诊于深圳市人民医院口腔医学中心口腔黏膜病专科门诊的充血糜烂型和溃疡型OLP患者58例，随机分为试验组和对照组（各29例）。分别采用白芍总苷联合曲安奈德（试验组）及单纯使用曲安奈德（对照组）治疗，同时采用视觉类比量表（VAS）和REU评分量表进行症状和体征记分，评价治疗后1个月和3个月的疗效。结果    治疗后1个月复诊，试验组总有效率为82.8%（24/29），对照组总有效率为79.3%（23/29），两组差异无统计学意义（χ2 = 0.112，P > 0.05）；治疗后3个月复诊，试验组总有效率为86.2%（25/29），对照组总有效率为51.7%（15/29），两组差异有统计学意义（χ2 = 15.241，P < 0.01）。结论    白芍总苷联合曲安奈德可有效治疗OLP，白芍总苷可做为联合用药和病程缓解期的合理选择。

关键词: 白芍总苷, 曲安奈德, 口腔扁平苔藓