Abstract: The goal of periodontal regeneration is to reconstruct a functional periodontal ligament-cementum-alveolar bone complex. Previous studies have primarily focused on anti-infection and inflammation control，yet recent evidence indicates that the mechanical microenvironment（e.g.，orthodontic forces，occlusal load，extracellular matrix stiffness，and viscoelasticity）serves as a critical background variable determining cellular fate. Moreover，it can substantially influence regenerative outcomes by modulating the immune microenvironment and bone remodeling processes. At the molecular level，mechanically sensitive ion channels，integrin-focal adhesion kinase complexes，and nuclear mechanosensitive structures collectively form a mechano-transduction network that converts mechanical stimuli into Ca2+ influx，RhoA/ROCK pathway activation，and transcriptional programs such as YAP/TAZ and β-catenin，thereby precisely regulating periodontal tissue repair and regeneration. At the translational level，biomaterials with programmable mechanical parameters（e.g.，stress relaxation，topological structure）have demonstrated potential of regulation beyond spatial maintenance. Clinical studies confirm the feasibility of  combined periodontal-orthodontic therapy under well-controlled inflammation，where timely and controllable orthodontic mechanical stimuli can be integrated into regenerative strategies. This article elaborates on the molecular mechanisms，experimental evidence，and clinical translation potential of mechanical signal regulation in periodontal regeneration，aiming to provide new perspectives for clinical decision-making and future research direction in combined periodontal-orthodontic therapy.

Key words: mechanical signals, periodontal regeneration, mechanotransduction, combined periodontal-orthodontic therapy

摘要： 牙周再生（periodontal regeneration）的目标是重建具有功能性的牙周组织（牙周膜-牙骨质-牙槽骨复合体）。既往研究多聚焦于抗感染与控制炎症，近年来证据表明，力学微环境（如正畸力、咬合负荷、细胞外基质刚度与黏弹性等）不仅是决定细胞命运的关键变量，亦能通过调节免疫微环境与骨改建过程，实质性影响再生结局。在分子层面，机械敏感离子通道、整合素-黏着斑复合体及细胞核机械耦合结构共同构成机械信号转导网络，将力学刺激转化为钙离子（Ca2+）内流、RhoA/ROCK通路激活及YAP/TAZ、β-连环蛋白（β-catenin）等转录激活，从而精确调控牙周组织修复与重建。在转化层面，具有可编程力学参数（如应力松弛、弹性模量）的生物材料展现出超越单纯空间维持的调控潜能。临床研究证实，在炎症控制良好的前提下，牙周-正畸联合治疗具有可行性，适时、可控的正畸力刺激可被整合进入再生策略。文章就力学信号调控牙周再生的分子机制、实验证据及临床转化潜力展开阐述，以期为牙周-正畸联合治疗未来研究方向及临床决策提供新视角。

关键词: 力学信号, 牙周再生, 机械转导, 牙周-正畸联合治疗