关键词: 非可控炎症, 口腔癌, 癌变, 调控节点

Abstract: Abstract：Non-resolving inflammation may initiate cancerazation and is involved in cancer occurrence， development， metastasis， drug resistance and various pathological processes. Previous Studies suggested that critical network nodes in regulation of carcinogenesis were closely associated with signaling pathways related to stimulation， immunization， stress and inflammation. Particularly，NF-κB pathway in non-resolving inflammation and cancer metastasis plays a key regulatory role in carcinogenesis. In carcinogenesis of oral mucosa， upstream regulatory networks of miRNAs play a critical role. Using the non-resolving (chronic) inflammation malignant transformation models， such as oral lichen planus and multiple-step carcinogenesis models， it will establish malignant transformation spatiotemporal nodes and miRNA or mRNA expression patterns related to the processes of carcinogenesis， promoting and development. It will also investigate the dynamic relationship between non-resolving inflammation and oral cancer through the comprehensive utilization of medical statistics， biological informatics analysis and the integration analysis on epigenetics and genetics levels. No doubt， to determine the basic regulatory network of malignant transformation nodes and key factors of carcinogenesis， the novel cancer treatment model， "anti-inflammatory"， will provide rationale and effective interventions targeting in the future.

Key words: non-resolving inflammation, oral cancer, carcinogenesis, regulatory network node