中国实用口腔科杂志

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口腔来源外泌体研究进展

史亚方彭文英林莉   

  1. 中国医科大学口腔医学院·附属口腔医院牙周科,辽宁  沈阳  110002
  • 出版日期:2018-03-15 发布日期:2018-04-17
  • 基金资助:

    国家自然科学基金(81470744);辽宁省自然科学基金(2014021067)

  • Online:2018-03-15 Published:2018-04-17

摘要:

外泌体指从各种类型细胞中分泌的直径为40~100 nm的细胞外囊泡,其内含有来自细胞的脂质、蛋白质、核酸,可以通过质膜融合、表面受体介导的摄取、受体细胞内化等机制被装载到受体细胞,影响其功能和活动。外泌体中包含的RNA和miRNA可以随外泌体转移到受体细胞,并在受体细胞中被翻译,是遗传交换的新载体。口腔领域对外泌体的研究主要集中在外泌体介导细胞间通讯和调节免疫活性方面。文章通过对唾液、口腔癌和牙周致病菌来源的外泌体进行综述,总结口腔领域的外泌体研究进展。

关键词: 外泌体, 唾液, 口腔癌, 牙周致病菌

Abstract:

Exosomes refer to 40~100 nm extracellular vesicles secreted from various types of cells that contain cell's lipid,proteins and nucleic acids,which can be accessed to recipient cell by plasma membrane fusion,surface receptor-mediated uptake,and cell internalization,affecting the function and activity of the recipient cell. The RNA and miRNA contained in exosomes can be transferred with the exosomes to the recipient cells,and are translated in the recipient cells,which is a new carrier of genetic exchange. The research of exosomes in oral field focuses on exosome-mediated cell communication and modulating immunocompetence. In this paper,the exosomes derived from salivary origin,oral cancer sources and periodontal pathogens were reviewed to summarize the research progress in exosomes of the oral area.

Key words: exosome;saliva;oral , cancer;periodontal pathogens