中国实用口腔科杂志

中国实用口腔科杂志 ›› 2012, Vol. 5 ›› Issue (05): 287-290.

• 论著 • 上一篇    下一篇

表皮生长因子受体与核因子κB p65在舌鳞状细胞癌组织中表达及相关性研究

  

  1. 1.佳木斯市中心医院口腔颌面外科，黑龙江  佳木斯  154002；2.佳木斯大学口腔医院口腔颌面外科，黑龙江  佳木斯 154004
  • 收稿日期:2012-03-05 修回日期:2012-04-26 出版日期:2012-05-15 发布日期:2012-07-05

  • Received:2012-03-05 Revised:2012-04-26 Online:2012-05-15 Published:2012-07-05

摘要： 目的    探讨表皮生长因子受体（EGFR）与核因子-κB p65（NF-κB p65）在舌鳞状细胞癌（TSCC）中的表达特征及二者间的相关性。方法    选取2002年1月至2009年12月佳木斯大学第二附属医院（口腔医院）口腔颌面外科手术切除TSCC组织标本43例；另选择来源于同期因舌部良性病变而手术切除的病变周围正常舌组织标本15例。采用免疫组化法检测组织中EGFR、NF-κB p65的表达。结果    TSCC组织中EGFR、NF-κB p65的阳性表达率分别为72.1%、67.4%。TSCC患者EGFR和NF-κB p65的表达在不同性别、年龄、病理组织分型方面差异无统计学意义（P > 0.05），而在TNM分期及有无淋巴结转移方面差异有统计学意义（P < 0.05）。EGFR与NF-κB p65表达呈正相关关系（r = 0.741，P < 0.01）。结论    EGFR和NF-κB p65在TSCC组织中呈过表达，二者的联合检测可以作为判断TSCC生物学行为和指导临床治疗的指标。

关键词: 舌鳞状细胞癌, 表皮生长因子受体, NF-&kappa, B p65, 免疫组化

Abstract: Objective    To explore the expressions of EGFR and NF-κB p65 in tongue squamous cell carcinoma and the correlation between EGFR and NF-κB p65. Methods    Immunohistochemistry SP method was performed to measure the situation expression in 43 cases of TSCC and 15 cases of nomal tongue tissue. Results    The positive expression rate of EGFR and NF-κB p65 was 72.1% and 67.4% in tumor tissue samples，higher than that in normal tissue samples（P < 0.01）.The expression of EGFR and NF-κB p65 was correlated with TNM stages and lymph node metastases（P < 0.05），and neither of them was correlated with age and sex（P > 0.05）. The level of EGFR protein positively correlated with that of NF-κB p65（r = 0.741，P < 0.01）。Conclusion    EGFR and NF-κB p65 are overexpressed in TSCC；it is closely correlated with its occurrence and development. And both of them jointly may be indicator to determine biological behaviors and clinical therapy of TSCC.

Key words: tongue squamous cell carcinoma, epidermal growth factor receptor, NF-&kappa, B p65, immunohistochemistry