中国实用口腔科杂志

中国实用口腔科杂志 ›› 2010, Vol. 3 ›› Issue (11): 667-669.

• 论著 • 上一篇    下一篇

血管内皮细胞生长因子和环氧化酶-2在血管瘤中表达的研究

  

  1. 中国医科大学口腔医学院口腔颌面外科，沈阳  110002
  • 收稿日期:2010-09-20 修回日期:2010-10-23 出版日期:2010-11-15 发布日期:2010-12-10

  • Received:2010-09-20 Revised:2010-10-23 Online:2010-11-15 Published:2010-12-10

摘要：

目的    探讨血管内皮细胞生长因子（VEGF）和环氧化酶-2（COX-2）在血管瘤中的表达。方法    收集2005—2007年中国医科大学盛京医院病理科皮肤血管瘤标本30例及同期的血管畸形标本26例（对照），采用免疫组化SABC法分别检测其中VEGF和COX-2的表达。结果    VEGF在血管瘤标本中均呈阳性表达，阳性率为100%，而在血管畸形标本中阳性率为 46.15%，两组之间的差异有统计学意义（P < 0.05）。COX-2在血管瘤标本中阳性率为93.33%，在血管畸形标本中的阳性率为42.30%，两组之间的差异有统计学意义（P < 0.05）。结论         VEGF和COX-2在血管瘤血管内皮细胞上高表达，促进血管瘤增殖；在血管畸形的血管内皮细胞中低表达。其表达情况为临床治疗血管瘤提供了一种新思路。

关键词: 血管瘤, 血管畸形, 血管内皮细胞生长因子, 环氧化酶-2

Abstract:

Objective    To investigate the role of VEGF and COX-2 in dermal hemangiomas. Methods    By SABC method， the expression of VEGF and COX-2 was observed in the 30 hemangiomas， 26 vascular malformations and 6 normal skins. Statistical analysis was performed using SPSS 11.0. Results    The positive rate of VEGF in hemangiomas was 100% and in vascular malformations it was 46.15%， there being significant difference between the two groups（P < 0.05）. The positive rate of COX-2 in hemangiomas was 93.33% and in vascular malformations it was 42.30%， there being significant difference between the two groups（P < 0.05）. Conclusion    The higher expression of VEGF and COX-2 in hemangiomas could stimulate the development of hemangioma；the expression of VEGF and COX-2 in vascular malformations and normal skins were low or negative. This could provide a new concept to therapy for hemangiomas.

Key words: hemangiomas； vascular malformations； VEGF； COX-2