关键词: 婴幼儿血管瘤, 普萘洛尔, 马来酸噻吗洛尔, 腮腺区

Abstract:

Objective　To assess the efficacy of oral propranolol combined with topical timolol maleate in the treatment of infantile parotid hemangiomas. Methods　Twenty-seven infants with parotid hemangiomas were hospitalized in Department of Oral and Maxillofacial Surgery， Hospital of Stomatology， China Medical University，from September 2013 to September 2015. The study group consisted of 9 males and 17 females， aged between 2 months to 9 months， with a median age of 4.8 months. The lesions were all located in the parotid region，and measured between 1.5 cm × 2.0 cm × 1.0 cm and 7.0 cm × 6.0 cm ×3.0 cm in size. Propranolol was administered orally at a dose of 1.0～1.5 mg/（kg·d）， 0.5% timolol maleate eye drop solution was applied topically with medical cotton swabs to the area of the lesion twice a day. The therapy duration was 12 to 32 weeks， averaged 20.3 weeks. The follow-up duration was from 3 months to 12 months， averaged 8.4 months. Record the colors， volumes， textures， and ultrasonic results of hemangiomas before the treatments and at the end of treatments. Results　Of the 27 patients，21 demonstrated an excellent response （77.8%），4 showed a good response （14.8%），and 2 displayed a moderate response （7.4%）；cure rate was 77.8%，and effective rate was 100%. Conclusion　Overall，oral propranolol combined with topical timolol maleate is an effective treatment method for infantile parotid hemangioma，and is worth promoting.

Key words: infantile hemangioma, propranolol, timolol maleate, parotid