中国实用口腔科杂志

中国实用口腔科杂志 ›› 2013, Vol. 5 ›› Issue (2): 89-92.

• 论著 • 上一篇    下一篇

PAN/CS/BCP/川续断复合支架材料修复牙槽骨缺损实验研究

赵刚，沈子童，李德超，蒋丽妍   

  1. 作者单位：佳木斯大学口腔医学院，黑龙江佳木斯154007
  • 出版日期:2013-03-01 发布日期:2013-03-29
  • 通讯作者: 沈子童

Experimental research of PAN/CS/BCP/teasel composite scaffold material in repairing alveolar bone defect

ZHAO Gang，SHEN Zi-tong，LI De-chao，JIANG Li-yan   

  1. Jiamusi University School of Stomatology，Jiamusi 154007，China
  • Online:2013-03-01 Published:2013-03-29

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摘要： 目的 研究多孔聚丙烯晴基碳纤维/壳聚糖/双相磷酸钙/川续断（PAN/CS/BCP/川续断）复合支架材料对牙槽骨缺损区的骨愈合及修复作用。方法 本研究于2011年10月至2012年4月在佳木斯大学动物实验中心及佳木斯大学基础医学院完成。选用24只新西兰大白兔制成下颌双侧10 mm直径的圆型人工牙槽骨缺损模型。随机等分为实验组（植入PAN/CS/BCP/川续断复合支架材料）和对照组（植入壳聚糖/纳米羟基磷灰石）。分别于4、8、12周各处死动物2只，进行骨密度值分析及组织学观察。结果 （1）12周时，实验组骨缺损处边缘为高密度阻射影，边缘连续且密度与正常骨组织一致。（2）各个时期内实验组新骨生成均较对照组快，且新生骨骨密度均高于对照组。（3）组织形态观察：HE染色显示，12周时实验组牙槽骨的缺损区可见骨化线及较规则骨组织形成。结论 PAN/CS/BCP/川续断复合支架材料有加快骨再生的能力，对骨的愈合有促进作用。

Abstract: Abstract：Objective To study the role of PAN/CS/BCP/teasel composite scaffold material in bone healing and repair of alveolar bone defect. Methods Totally 24 rabbits were made into alveolar bone defect models with bilateral diameter of 10 mm， and they were divided into two groups: PAN/CS/BCP/teasel group （experiment group） and control group （implanted with chitosan/nano hydroxyapatite）. Respectively at the end of 4， 8 and 12 weeks， two rabbits in each group were put to death in order to make bone density analysis and histological observation. Results （1） In experiment group， the bone defect edge showed high density resistance photograph and its density was the same as normal bone tissue. （2） For each period， the new bone formation rate in the experiment group was higher that in the control group. （3） Histological observation: HE dyeing showed ossification line and relatively regular bone formation.Conclusion PAN/CS/BCP/teasel composte scaffold material can hasten bone regeneration and promote bone healing.

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