中国实用口腔科杂志

中国实用口腔科杂志 ›› 2012, Vol. 5 ›› Issue (12): 728-732.

• 专题笔谈 • 上一篇    下一篇

头颈部滑膜肉瘤诊治研究进展

季彤，马春跃   

  1. 上海交通大学医学院附属第九人民医院口腔颌面—头颈肿瘤科，上海  200011
  • 出版日期:2012-12-15 发布日期:2013-01-06
  • 作者简介:季彤，主任医师、 硕士研究生导师。1993年本科毕业于华西医科大学，获得学士学位； 2004年于上海第二医科大学获得博士学位。现工作于上海交通大学医学院附属第九人民医院口腔颌面—头颈肿瘤科。兼任中国抗癌协会头颈肿瘤专业委员会委员，中华口腔医学会口腔颌面外科专业委员会肿瘤学组副组长，国际内固定协会（AO）讲师等职务。主要研究方向为头颈肿瘤的临床及基础研究。近几年负责国家自然科学基金等课题6项，参加各类科研课题7项，发表学术论文50余篇（SCI收录12篇），参编专著8部，合作申请专利4项。已入选二医大“百人计划”、“二医大优秀青年教师”和附属九院“优秀青年骨干计划”。

Research progress in diagnosis and treatment of synovial sarcoma of the head and neck

JI Tong， MA Chun-yue   

  1. Department of Oral and Maxillofacial Surgery， Ninth People’s Hospital， School of Medicine， Shanghai Jiao Tong University， Shanghai 200011， China
  • Online:2012-12-15 Published:2013-01-06

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摘要： 摘要：滑膜肉瘤占所有软组织肉瘤的6%～9%，多发生于下肢及躯干部位，且多见于关节旁软组织内，病变恶性程度较高，有其特定的病理诊断标准及分子发病机制。由于存在不同亚型及病变发展较为迅速，对手术医生、放化疗医生而言，滑膜肉瘤的治疗仍是较大的挑战。位于头颈部原发的滑膜肉瘤较为少见，仅占所有滑膜肉瘤病例的3%～5％，因此对于其临床病理资料的研究也较少。通过查阅最新文献资料及回顾我院的头颈部滑膜肉瘤病例资料，我们认为手术+术后放疗的方法仍可做为滑膜肉瘤的首选治疗方法。但对于化疗治疗效果，仍需进一步评价。

关键词: 滑膜肉瘤, 染色体融合, 手术, 放疗, 化疗

Abstract:  Abstract：Synovial sarcoma accounts for about 6%～9% of soft tissue sarcomas， most commonly affecting the extremity of adults. Synovial sarcomas often develop in para-articular regions of the extremity， and they almost never arise within the joint. Synovial sarcomas have always been considered high-grade and carry a particularly different molecular mechanism and its pathological diagnosis remains distinct. Given the rapid growth and infiltrative nature of the disease， local and systemic control is challenging and tough to surgeons， radio-oncologists and chemo-therapists. Head and neck synovial sarcomas are rare entities in adults， accounting for only about 3%～5% of all synovial sarcomas. Therefore， the medical literature on synovial sarcomas of the head and neck is so far limited. After reviewing the latest published articles and summarizing the cases in our hospital， we advocate surgery and post-surgical radiation as the primary treatment modality. As for chemotherapy， the potential survival benefit remains controversial.

Key words: synovial sarcoma, chromosome fusion, surgery, radiotherapy, chemotherapy

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