关键词: 颌面软组织, 再生, 种子细胞, 生长因子, 生物支架

Abstract:

Maxillofacial soft and hard tissue， which has special anatomical site and physical structure， plays a vital role in the mastication， pronunciation， appearance and other physical functions in human. However， maxillofacial tissue is vulnerable to trauma， infection and congenital diseases. Maxillofacial tissue defects are very common in clinical practice， seriously affecting the physiological function and life quality of patients. Nowadays， the major repair methods applied in clinic are autologous transplantation， which results in second trauma and incomplete structural and functional repair， so the reconstruction of maxillofacial tissue defect is a difficult clinical problem urgent to be solved. The maxillofacial soft tissue has complex composition and structure and is directly exposed to saliva， which is more demanding for repair materials and repair strategies. In recent years， with the development of tissue engineering and regenerative medicine， more and more attention has been paid to the regeneration of maxillofacial region， which provides a promising treatment strategy for maxillofacial soft tissue defects. In this paper， the research progress of the maxillofacial soft tissue regeneration， which mainly refers to seed cells， growth factors， biological scaffold and repair strategies，is reviewed.

Key words: maxillofacial soft tissue, regeneration, seed cell, growth factor, scaffold