关键词: 甲苯胺蓝, 抗微生物, 抗肿瘤, 光动力疗法

Abstract:

Toluidine blue （TB），an alkaline thiazide cationic dye，which can be combined with the acidic substances in the tissue cells，is an important dye for nucleic acid staining. Because of the specific binding of TB to nucleic acids，TB can be retained in cancer tissue preferentially and widely used in the diagnosis of malignant tumors of the mouth，the eye，and the upper digestive tract. TB plays an important role in medical research. In addition，as an effective photosensitizer，TB can be widely used in photodynamic antimicrobial and antitumor therapy. The purpose of this review is to provide a summary about the research situation and the application of TB in oral medicine.

Key words: toluidine blue, TB；antimicrobial；antitumor；photodynamic therapy