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02 September 2018, Volume 34 Issue 9 Previous Issue    Next Issue

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Metabolic disorders during pregnancy and placenta development. FAN Xiu-jun，HUANG Chen 2018, 34(9): 959-963.  DOI: 10.19538/j.fk2018090103 Abstract ( )   Usually，the symptoms of metabolic disorders during pregnancy are relieved or disappear completely or partially when the fetuses and/or the placenta is delivered.So，the presence of fetus and/or the placenta has been believed to be the main cause or trigger of the metabolic disorders during pregnancy.In this review，we summarize the recent research progress and new approaches related to the investigation of metabolic disorders during pregnancy and placenta development，hoping to provide reference for the diagnosis and treatment of the diseases and improve the health of mother and child during pregnancy and postpartum through understanding the existing research progress and methods as well as the recent research trend.

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Maternal lipid metabolism and fetal growth. LI Ting，DUAN Tao 2018, 34(9): 963-966.  DOI: 10.19538/j.fk2018090104 Abstract ( )   Changes in lipid metabolism during gestation is essential for fetal development.During early and middle pregnancy，there is an increased accumulation of fat synthesis in the mother，which switches to an increased lipolysis and maternal hyperlipidemia during the last trimester.Dyslipidemia affects fetal development which can cause macrosomia or fetal growth retardation.The effect of dyslipidemia on offspring can persist to their adult stage，even if the diet style is adjusted after birth.

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Lipid and fatty acid metabolism disorders and preeclampsia. WANG Guang-jiao，YANG Zi 2018, 34(9): 966-970.  DOI: 10.19538/j.fk2018090105 Abstract ( )   Preeclampsia is a syndrome manifestation due to multiple factors，multiple mechanisms，and multiple pathways.Abnormalities of maternal lipid metabolism and fatty acid metabolism before pregnancy and during pregnancy play an important role in the development of some preeclampsia. To understand the effects of genetic，environmental，nutritional factors and the effects of basic and underlying diseases on lipid metabolism and fatty acid metabolism associated with preeclampsia helps to get a deep understanding of the pathogenesis of multiple factors，multiple mechanisms，and multiple pathways in preeclampsia.

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Application of metabolomics in preeclampsia prediction and diagnosis. UN Li-zhou，JIANG Zi-yan 2018, 34(9): 970-973.  DOI: 10.19538/j.fk2018090106 Abstract ( )   We detected the expression of metabolites in serum，urine and placental tissue by different metabolomic technologies.We put forward that the combination of a variety of metabolites could  significantly increase the sensitivity and specificity of prediction and diagnosis of pre-elampsia，especially the early-onset preeclampsia. The study will provide good makers for the prediction and diagnosis of preeclampsia.

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Relationship between gestational diabetes mellitus and intestinal microbiome. DENG Ya-li，DING Yi-ling 2018, 34(9): 974-976.  DOI: 10.19538/j.fk2018090107 Abstract ( )   Gestational diabetes mellitus is a peculiar disease，which is serious threat to the pregnancy outcomes and the health of their offspring.In recent years，the increasing studies of intestinal microbiome reveal that intestinal microbiome can promote the occurrence and development of gestational diabetes，and at the same time adjusting and changing intestinal flora can prevent and improve play a positive role.

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Healthy lifestyle management for gestational diabetes mellitus. ANG Zi-lian，CHEN Han-qing 2018, 34(9): 976-979.  DOI: 10.19538/j.fk2018090108 Abstract ( )   Gestational diabetes mellitus（GDM）is a common complication during pregnancy.Lifestyle intervention is an important treatment for GDM.The  Healthy lifestyle management by standardized，professional and multi-disciplinary team helps to control blood glucose，improving the adverse pregnancy outcome of GDM and the prognosis of the mothers and fetus.

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Maternal and child cardiovascular risk and prevention of preeclampsia. LI Yu-ming，YANG Ning 2018, 34(9): 979-983.  DOI: 10.19538/j.fk2018090109 Abstract ( )   Preeclampsia is an essential cardiovascular risk exposure during pregnancy，which increases the  risks of cardiovascular diseases in mothers and children later in life .Strengthening clinical monitoring，risk factors assessment and early intervention will promote cardiovascular health of preeclampsia women and their children.Early screening and intervention of preeclampsia is one of the keys to the prevention of cardiovascular risk during pregnancy.In addition to medication，weight control，screening and treatment of obstructive sleep apnea（OSAS），and salt reduction can not be ignored.

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Gestational weight gain and blood pressure regulation. ZHOU Xin 2018, 34(9): 983-986.  DOI: 10.19538/j.fk2018090110 Abstract ( )   Excessive gestational weight gain（GWG）is closely associated with elevated blood pressure（BP）levels，postpartum weight retention and obesity.Recent studies have shown that the maximum GWG rate occurs between 22+0 to 26+0 weeks of gestation，which is a critical time window associated with diastolic BP rebound.Interventions that target this period may improve maternal and fetal outcomes by optimizing GWG and BP levels.

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Metabolic syndrome and recurrent pregnancy loss. YANG Li，ZHANG Hong 2018, 34(9): 986-989.  DOI: 10.19538/j.fk2018090111 Abstract ( )   Elevated incidence of recurrent pregnancy loss is found in the women with metabolic syndrome.The mechanism may be in association with prothrombotic state，poor endometrial decidualization，luteal phase deficiency，and maternal-fetal interface immune dysfunction.Lifestyle modification，weight reduction，blood glucose control，luteal phase support，and anti-coagulation may improve future pregnancy outcomes.

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Gestational metabolic syndrome：a scientific issue worthy of in-depth investigation. WU Lin-lin，LEI Qiong 2018, 34(9): 989-993.  DOI: 10.19538/j.fk2018090112 Abstract ( )   Gestational metabolic syndrome（GMS）is recognized as a special form of metabolic syndrome，which is characterized by the clustering of the following symptoms：pre-pregnancy overweight/obesity，alterations in lipid and glucose metabolism，and high blood pressure.Recent evidence shows that GMS is associated with adverse pregnancy outcomes and long-term cardiometabolic risk for mothers and their offspring.GMS remains to be an open scientific issue，which warrants further in-depth investigation.