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02 March 2018, Volume 34 Issue 3 Previous Issue    Next Issue

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Diagnosis and genetic analysis of premature ovarian insufficiency WU Jie 2018, 34(3): 243-245.  DOI: 10.19538/j.fk2018030102 Abstract ( )   Premature ovarian insufficiency （POI） refers to ovarian impairment/failure before the age of 40 years in women.The prevalence of POI is reported about 1%.The quality of life of POI patients is affected and POI women are partly responsible for the infertility in reproductive field.As the understanding in POI is deepened，the diagnosis criteria of POI have been changed recently.The etiology of POI is complicated，which includes the genetic factor，autoimmune and metabolic factors，iatrogenic and so forth.Here the progress of diagnosis criterion and the genetic analysis of POI are addressed.

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Effects of premature ovarian insufficiency on bone metabolism LEI Xiao-min，TAN Xin-sha 2018, 34(3): 245-248.  DOI: 10.19538/j.fk2018030103 Abstract ( )   Osteoporosis，lipid metabolic abnormalities and cardiovascular diseases are present in POI patients.Osteoporosis has seriously affected people's health and quality of life，and has become a global public health problem.For young POI patients，the development of the disease can be controlled or slowed down if adequate cognition，early prevention and early treatment are made.In this paper，the changes of hormones in POI patients were taken as the starting point，and the mechanism of bone metabolism influenced by the changes of hormones was discussed，so as to strengthen the management of bone health.

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Effect of premature ovarian insufficiency on cardiovascular disease SHI Hui-rong，LI Xia 2018, 34(3): 248-251.  DOI: 10.19538/j.fk2018030104 Abstract ( )   The risk of cardiovascular disease is higher in patients with premature ovarian insufficiency than in individuals of the same age.There is still a lack of effective screening for the risk of cardiovascular disease in patients with premature ovarian insufficiency.Endogenous estrogen has a protective effect on cardiovascular system，and timely and appropriate hormone replacement therapy can delay the occurrence of cardiovascular disease.

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Influence of premature ovarian insufficiency on neurological function WANG Yan，WANG Li-ping 2018, 34(3): 251-255.  DOI: 10.19538/j.fk2018030105 Abstract ( )   The majority of observational studies shows that estrogen deficiency may result in negative effects on neurological function，especially in patients with premature ovarian insufficiency（POI）.However，the direct evidence and the strong quality of evidence is limited.Early onset of hormone replacement treatment in POI is beneficial to preventing cognitive decline or low cognitive function，but it can’t completely correct the negative effects on neurological function caused by POI and menopause.Taking the influencing factors of occurrence and progression of POI seriously and slowing down the progress of the disease as far as possible，are the most important measures to prevent the damage to neurological function caused by POI.

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Adolescent induction of early-onset ovarian dysfunction ZHANG Yao，ZHANG Hui-jie 2018, 34(3): 255-258.  DOI: 10.19538/j.fk2018030106 Abstract ( )   Puberty induction is required when early onset ovarian dysfunction occurs before puberty.Continuous treatment must be performed from adolescence to adulthood.Far adolescent induction 17β estradiol is used；initial treatment should begin at the age of 12，starting with small doses，and gradually increasing the dose in 2-3 years.For patients with late diagnosis and those who do not consider terminal heights，the estrogen-enhancing regimen can be adopted.Oral contraceptives are not used in puberty induction.The application of periodic progesterone is only possible after the use of estrogen for at least two years or after the endometrial breakthrough hemorrhage.

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Fertility treatment for premature ovarian insufficiency ZHANG Xue-hong，WANG Li-yan 2018, 34(3): 258-261.  DOI: 10.19538/j.fk2018030107 Abstract ( )   Except for oocyte donation，there is no recognized effective way for premature ovarian insufficiency（POI） patients to obtain pregnance by autologous eggs.For the patients with fertility requirements，the methods of recovering ovary functions include treating the primary disease，adjusting ovulation induction protocol，and adding some assistant drugs.This article presents fertility treatment and prevention methods of POI.

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Hormone replacement treatment in women with premature ovarian insufficiency TANG Rui-yi，CHEN Rong 2018, 34(3): 261-265.  DOI: 10.19538/j.fk2018030108 Abstract ( )   Premature ovarian insufficiency（POI） describes a spectrum of declining ovarian function in women younger than 40 years，which has severe influence on health.In women with POI，hormone replacement treatment（HRT）is required and with lower risks.HRT is an effective approach to treat the symptoms of hypoestrogenism and mitigate long-term health risks if there are no contraindications to treatment.Systemic HRT with cyclic administration is recommended.The dose of estrogen in women with POI is higher，and the dose of progesterone is adjusted according to the dose of estrogen.During treatment evaluation for all women with POI should be done，and the treatment should last at least until the average age of natural menopause.