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02 May 2017, Volume 33 Issue 5 Previous Issue    Next Issue

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Application of MRI in diagnosis and treatment of endometrial cancer. HUANG Jing-wen，YANG Qi-hua 2017, 33(5): 444-449.  DOI: 10.19538/j.fk2017050102 Abstract ( )   Endometrial cancer is one of the three most common gynecologic malignancies. With high soft tissue resolution，multi-dimensional and multi-sequencing imaging，magnetic resonance imaging（MRI） has become an important method for preoperative staging of endometrial carcinoma. Conventional MRI plays an important role in preoperative staging，but still has some limitations. Functional MRI，such as diffusion weighted imaging（DWI） and dynamic contrast enhanced MRI（DCE-MRI），has great potential in preoperative staging. This review provides an overview of current conventional and novel imaging methods for preoperative staging of endometrial cancer.

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Application of hysteroscopy in the diagnosis and treatment of endometrial cancer. GUO Xue，GUAN Mei-mei 2017, 33(5): 449-451.  DOI: 10.19538/j.fk2017050103 Abstract ( )   Biopsy under hysteroscopy is more precise than curettage in the patients with early-stage endometrial cancer.In the meantime the lesion of cervical canal can be observed clearly，and doctors can make the initial staging，and through combining imaging procedures，doctors can make preliminary judgment of the range of tumor spread. Hysteroscopic operation with high dose of progesterone therapy，GnRH-a and Mirena can be used in the patients who try to reserve procreative function after strict screening.

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Clinical significance of sentinel lymph node mapping in endometrial carcinoma. WANG Yan- zhou，LIANG Zhi-qing 2017, 33(5): 451-454.  DOI: 10.19538/j.fk2017050104 Abstract ( )   Lymph node removal for staging，as part of the initial surgical management for patients with endometrial carcinoma，remains a controversial topic in gynecologic oncology. With the lack of prospective trials demonstrating a survival benefit for extensive lymphadenectomies，the rise of the minimally invasive surgical approach，and the increasing availability of novel near-IR imaging technologies and pathologic ultrastaging，lymphatic mapping has emerged as an increasingly popular option over the last few years.The clinical studies also showed its good prospect of application.However，the injection position and marker selection，paraaortic sentinel lymph node sampling，and other aspects also were faced with many problems.Therefore，it still needs further study whether sentinel lymph node mapping can replace endometrial cancer staging surgery.

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Role of laparoscopy in the treatment of endometrial cancer. KANG Shan 2017, 33(5): 454-458.  DOI: 10.19538/j.fk2017050105 Abstract ( )   With the continuous development of laparoscopy and energy equipment，the laparoscopic surgery technology develops rapidly at the same time. Now laparoscopic surgery for endometrial cancer has become the earliest matured technology in gynecologic oncology.It has achieved the same or better efficacy than laparotomy in terms of overall survival rate，recurrence-free survival rate，surgical time，blood loss，operative complication ，the quality of life and so on. So ，laparoscopic surgery plays an increasingly important role in endometrial cancer and gains more preference among doctors and patients.

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Fertility-preserving treatment for young women with early-stage endometrial cancer. ZHANG Shi-qian，YU Hao 2017, 33(5): 458-461.  DOI: 10.19538/j.fk2017050106 Abstract ( )   With the delay of pregnancy age，there is an increasing likelihood of raised percentage of young females with early-stage endometrial cancer. Considering the favourable prognostic features，such as focal lesion and well-differentiated lesion and being able to respond to progestin，the treatment of fertility- preserving has been paid more attention. This paper elucidated the strategies of fertility-preserving treatment in young women.

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Surgical treatment for endometrial cancer. XIA Ling-fang，WU Xiao-hua 2017, 33(5): 461-465.  DOI: 10.19538/j.fk2017050107 Abstract ( )   Surgical treatment is the corner stone for endometrial cancer. Although there are many controversies，comprehensive staging surgery for the early stage of endometrial cancer is still the main choice，and for the advanced stage，optimal cytoreductive surgery is needed.We will talk about the surgical treatment for early，late stage and recurrence of endometrial cancer in this article.

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Radiation therapy for endometrial carcinoma.   HOU Xiao-rong，ZHANG Fu-quan 2017, 33(5): 465-469.  DOI: 10.19538/j.fk2017050108 Abstract ( )   Radiation therapy is crucial in the management of endometrial carcinoma，whether used as an adjuvant treatment after surgery or as definitive treatment for women who are medically inoperable. Adjuvant radiotherapy decreases the risk of local recurrence for patients with adverse pathologic features. Definitive radiotherapy is a good option for inoperable patients.Radiotherapy may include external beam radiotherapy and vaginal intracavity brachytherapy.

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Chemotherapy and hormonal therapy for endometrial cancers. GAO Yu-nong 2017, 33(5): 469-472.  DOI: 10.19538/j.fk2017050109 Abstract ( )   The objective of this essay is to conduct a critical appraisal of the published literature and clinical practices on the use of adjuvant chemotherapy and neo-adjuvant chemotherapy in the treatment of endometrial cancers. Chemotherapy is often recommended for high-risk subsets of stage Ⅰ disease . Level Ⅰ evidence exists for use of adjuvant chemotherapy in stage Ⅲc endometrial cancer，although results of randomized trials have trials. Carboplatin plus paclitaxel is the current standard regimen，based on extrapolation of data from the metastatic setting. Neo-adjuvant chemotherapy is performed followed by interval debulking for patients with poor performance status or those patients who the surgeon believes will have suboptimal debulking if surgery is attempted. Although hormonal therapy is not recommended in the adjuvant setting，it remains useful in the treatment of metastatic disease，particularly for tumors of low-grade endometrioid histology with a long time to recur.

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Targeted therapy for endometrial cancer. FENG Feng-zhi，FAN Chen-chen 2017, 33(5): 472-476.  DOI: 10.19538/j.fk2017050110 Abstract ( )   Endometrial cancer is a common gynecologic malignancy. Despite advances in radiotherapy，surgery，and chemotherapeutic strategies，the prognosis of women with recurrent or advanced endometrial cancer is poor. The most promising treatment for cancers that progress after standard therapy might be targeted therapy. A review of available literature was conducted concerning the current targeted therapy available for endometrial cancer.

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Treatment for aggressive subtype of endometrial carcinomas. LIU Kai-jiang 2017, 33(5): 476-479.  DOI: 10.19538/j.fk2017050111 Abstract ( )   The disparate genetic alterations of aggressive subtype of endometrial cancer determine its specificities in terms of clinical features，extent of surgery，clinical prognosis and other aspects. Clinicians should raise awareness of this specific subtype of endometrial cancer.Careful initial evaluation，comprehensive surgical staging and adjuvant therapy with platinum-based chemotherapy combined with tumor-directed radiotherapy should be performed to improve the prognosis.