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02 May 2016, Volume 32 Issue 5 Previous Issue    Next Issue

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Misunderstanding of human papillomavirus（HPV） detection in clinical application. SUI Long，CONG Qing. 2016, 32(5): 395-398.  DOI: 10.7504/fk2016040104 Abstract ( )   Abstract:Persistent cervical infection with high-risk human papillomavirus（HPV） genotypes is the main cause of the development of cervical cancer and precancer.HPV detection effectively improves the sensitivity of cervical cancer detection and becomes an important method of cervical cancer screening.However，due to wide variety of HPV detection methods，differences among various detection methods，principles and clinical cut-off value and so on，clinicians tend to have some misunderstandings in their clinical application.

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Significance of abnormal colposcopic appearance in cervical lesion screening. QIAN De-ying. 2016, 32(5): 399-402.  DOI: 10.7504/fk2016040105 Abstract ( )   Abstract:Colposcopy is an important instrument in early screening of cervical cancer and precancerous lesions.A variety of abnormal colposcopic appearances in cervical lesion screen is mentioned in this text.The risk precedence order is acetowhite epithelium，punctuation，cuffed crypt openings，mosaic，schiller test negative coloring，inner border sign，ridge sign，and atypical blood vessels.All of these abnormal signals should be appropriately treated according to their risk.

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Scientific evaluation of methods for endometrial cancer screening. WANG Jian-liu. 2016, 32(5): 402-405.  DOI: 10.7504/fk2016040106 Abstract ( )   Abstract:The incidence of endometrial cancer and high risk population are increasing recent years.We should pay more attention to the screening of endometrial cancer.Until now，three methods are used in clinics for endometrial cancer screening, which are endometrial cytological test （ECT），endometrial cell block and minimal endometrial biopsy.These methods have their own advantages and disadvantages.The optimal method of endometrial cancer screening needs to be further studied.

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Circulating tumor DNA and liquid biopsy in early screening of gynecologic tumor. ZHANG Shi-qian, HUANG Wen-qian. 2016, 32(5): 405-409.  DOI: 10.7504/fk2016040107 Abstract ( )   Abstract: The early detection of some gynecologic malignancies can significantly improve patient’s prognosis. Liquid biopsy is a new technology that use human’s body fluid to detect tumor-relating changes，e.g., tumor cells or tumor DNAs，in order to early detect tumor status and make diagnosis, but this method is immature and still in the pre-clinical experimental stage. We discussed the definition，characteristics，methods and applications and reviewed the meaning of circulating tumor DNA detection and its future prospects.

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Use of genetic testing in the screening of gynecologic malignancies. WANG Ze-hua，GUO Jing. 2016, 32(5): 409-413.  DOI: 10.7504/fk2016040108 Abstract ( )   Abstract: Cancer is considered a genetic disease.Inherited or acquired genetic disorders are involved in the malignant transformation and progression of tumors.In gynecologic oncology，genetic testing has captured global attention，especially in tumor screening.Currently，HPV testing plays an essential role in cervical cancer screening；the detection of BRCA1/2 and MLH1/MSH2 mutations has been strongly recommended to stratify patients who have a high risk of developing ovarian cancer and endometrial cancer，respectively.

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Value of digital 3D reconstruction skill in differential diagnosis of benign and malignant tumor. LIU Ping, CHEN Chun-lin. 2016, 32(5): 413-417.  DOI: 10.7504/fk2016040109 Abstract ( )   Abstract: All tissues and organs have their own fixed vascular supply system. All of the tumor blood supply systems are derived from the blood vessel of parasitic tissues or organs. The vascular networks of benign and malignant tumors have different characteristics, so it is helpful to distinguish maligant tumor from benign pelvic mass through analysis of the characteristics of the blood vessels of the tumor. CTA-based 3D reconstruction of abdominal and pelvic vessels can help us fully understand the blood supply of the tumor, which plays an important role in differential diagnosis of benign and malignant tumor.

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Obstacles and breakthroughs in application of CA125 to ovarian cancer diagnosis. XU Cong-jian, WANG Yi-sheng，YANG Zi-jian. 2016, 32(5): 417-421.  DOI: 10.7504/fk2016040110 Abstract ( )   Abstract: CA125 is the most important serum biomarker for the diagnosis of ovarian cancer. However，its low specificity has been the main drawback. CA125 molecule is a huge mucin，with large amount of glycan modifications. Due to the unique glycan structures synthesized by malignant cells，CA125 molecules produced by ovarian cancer carry glycan chains that are different from those in benign gynecological diseases. These CA125 subtypes may serve as better serum biomarkers for ovarian cancer diagnosis.

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Screening for cervical cancer during pregnancy. WANG Yu-dong，SUN Lu-lu. 2016, 32(5): 421-425.  DOI: 10.7504/fk2016040111 Abstract ( )   Abstract: Cervical cancer during pregnancy is a serious complication that affects maternal and fetal health during perinatal period.It is of great importance to understand the physiological characteristics of pregnancy，to master the character of cervical cancer during three trimesters of pregnancy，and accordingly to master the screening strategy of cervical cancer during pregnancy.It is also imporant to set up the standard of screening，to discover cervical cancer at early stage and to reduce the mortality of perinatal infant and fertile women.