Abstract: Age is an important index of human fertility potential， whether in spontaneous conception or in assisted reproductive technology.Along with the carrying out of the Two- child Policy， an increasing number of advanced age couples consult reproductive medicine doctors so as to conceive a baby.To conceive and deliver a baby at an advanced age is challenging，so many aspects need to be taken into consideration；for example， whether their physical fitness enables them to be pregnant， maternal and infant complications during pregnancy， congenital genetic defects and so on.It’ s essential to inform patients that advanced age may relate to unsuccessful trial ofassisted reproductive technology and the increased risk of obstetric and neonatal complications.Age-related decrease of gamete quality is the key factor，which may lead to the high risk of fertility of advanced age couples.This article comments on the problems of advanced age-related gametes.

Key words: advanced age, gametes, assisted reproductive technology

摘要： 无论是自然妊娠还是接受辅助生殖技术，年龄依然是生殖潜能的最重要的指标。在我国“二孩” 政策出台后， 高龄夫妇生育要求明显升高， 在生殖中心就诊的高龄夫妇明显增多。高龄夫妇的生育会带来方方面面的问题， 如高龄女性身体条件是否可以妊娠、 妊娠期母胎并发症、 子代遗传缺陷增加等。面对越来越多的高龄夫妇的生育需求， 很有必要提前告知其临床治疗预后、 母胎高风险等。高龄夫妇生育高风险的原因很多， 但高龄导致的配子质量的下降是关键因素。文章就高龄对女性卵子及男性精子的影响做一阐述。

关键词: 高龄, 配子, 辅助生殖技术