Perinatal genitourinary infections and preterm birth.

doi:10.7504/fk2016050110

Abstract

Abstract:

Abstract: Genitourinary infections are one of the most important factors to induce preterm birth.The risk of preterm delivery has been increased by any kind of genitourinary tract infection.The mechanisms of preterm birth have not been fully elucidated yet.Some evidences indicate that imbalance of immune homeostasis may play an important role， and prostaglandin may also increase the risk of preterm birth.What's more， the gene polymorphism can make something even clear.There are many scholars who have different opinions on the importances of early screening of perinatal genitourinary infections.However， early screening of urinary and reproductive tract infections to prevent premature is necessary for people at a high risk for preterm birth.

Key words: genitourinary infections, preterm birth

摘要：

泌尿生殖道感染是诱发早产的重要因素，无论何种泌尿生殖道感染，都有增加早产的风险。泌尿生殖道感染导致早产的机制尚不十分清楚，可能与免疫系统稳态的失衡、前列腺素分泌增加以及基因的多态性相关。早期筛查感染能否降低早产的发生率，不同的学者说法不一。但是，对早产高危人群，尽早进行泌尿生殖道感染的筛查对预防早产的益处是肯定的。

关键词: 泌尿生殖道感染, 早产

CLC Number:

R714.2

DU Juan，HUANG Zhen-jiao.. Perinatal genitourinary infections and preterm birth.[J]. Acta Metallurgica Sinica, DOI: 10.7504/fk2016050110.

杜鹃，黄贞姣. 围产期泌尿生殖道感染与早产[J]. 中国实用妇科与产科杂志, DOI: 10.7504/fk2016050110.

References

[1]     Aagaard K，Riehle K，Ma J，et al.A metagenomic approach to characterization of the vaginal microbiome signature in pregnancy[J].PLoS One，2012，7（6）:e36466.

[2]     Romero R，Hassan SS，Gajer P，et al.The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women[J].Microbiome，2014，2:4.

[3]     Han YW，Shen T，Chung P，et al.Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth[J].J Clin Microbiol，2009，47:38-47.

[4]     Matoba N，Yu Y，Mestan K，et al.Differential patterns of 27 cord blood immune biomarkers across gestational age[J].Pediatrics，2009，123（5）:1320-1328.

[5]     Sadowsky DW，Novy MJ，Witkin SS，et al.Dexamethasone or interleukin-10 blocks interleukin-1p-induced uterine contractions in pregnant rhesus monkeys[J].Am J Obstet Gynecol，2003，188:252-263.

[6]     Wakabayashi A，Sawada K，Nakayama M，et al.Targeting interleukin-6 receptor inhibits preterm delivery induced by inflam mation[J].Mol Hum Reprod，2013，19（11）:718-726.

[7]     Yilmaz Y，Verdi H，Taneri A，et al.Maternal-fetal proinflammatory cytokine gene polymorphism and preterm birth[J].DNA Cell Biol，2012，31:92-97.

[8]     Leitich H，Bodner-Adler B，Brunbauer M，et al.Bacterial vaginosis as a risk factor for preterm delivery: a meta-analysis[J].Am J Obstet Gynecol，2003，189:139-147.

[9]     McDonald HM，Brocklehurst P，Gordon A.Antibiotics for treating bacterial vaginosis in pregnancy[J].Cochrane Database Syst Rev，2007，24（1）:CD000262.

[10]     Brocklehurst P，Gordon A，Heatley E，et al.Antibiotics for treating bacterial vaginosis in pregnancy[J].Cochrane Database Syst Rev，2013，31:CD000262.

[11]     Silver BJ，Guy RJ，Kaldor JM，et al.Trichomonas vaginalis as a cause of perinatal morbidity: a systematic review and meta-analysis[J].Sex Transm Dis，2014，41（6）:369-376.

[12]     Farr A，Kiss H，Holzer I，et al.Effect of asymptomatic vaginal colonization with Candida albicans on pregnancy outcome[J].Acta Obstet Gynecol Scand，2015，94（9）:989-996.

[13]     Rours GI，Duijts L，Moll HA，et al.Chlamydia trachomatis infection during pregnancy associated with preterm delivery: a population-based prospective cohort study[J].Eur J Epidemiol，2011，26:493-502.

[14]     Johnson HL，Ghanem KG，Zenilman JM，et al.Sexually transmitted infections and adverse pregnancy outcomes among women attending inner city public sexually transmitted diseases clinics[J].Sex Transm Dis，2011，38:167-171.

[15]     Workowski KA，Berman S.Centers for Disease Control and Prevention.Sexually transmitted diseases treatment guidelines 2010[J].MMWR Recomm Rep，2010，59:1-109.

（2016-03-10收稿）