Abstract:

Abstract:Objective Explore the expression of IGF-1R, VEGF-C and its relationship with cervical cancer lymph node metastasis.Methods Selected 50 cases of cervical squamous carcinoma tissues as the experimental group, 30 cases of normal cervical tissue as control group, using immunohistochemical SP method research the expression of IGF-1R, VEGF-C.Results The experimental group, lymph node metastasis was the positive expression of IGF-1R and VEGF-C ([WTBX]P[WTBZ]<0.05).Lymphatic vessel density marked by D2-40 in IGF-1R, VEGF-C positive expression group was significantly higher than negative group, and both positive expression in the experimental group were positively correlated.Conclusion The expression of IGF-1R,VEGF-C associated with cervical lymph node metastasis, lymphatic channel transfer has certain value for early judgment of cervical squamous carcinoma, joint detection both are important indicator of prognosis, and could guide clinical treatment.

Key words: cervical squamous cell carcinoma, immunohistochemical, IGF-1R, VEGF-C

摘要：

目的 研究宫颈癌中胰岛素样生长因子1受体(IGF-1R)和血管内皮生长因子C（VEGF-C）的表达及其与淋巴结转移关系。方法 选取河南科技大学第一附属医院2008年9月至2011年5月50例宫颈鳞癌组织为研究组，30例正常宫颈组织为对照组，应用SP免疫组化法研究IGF-1R、VEGF-C的表达情况。结果 研究组淋巴结转移与IGF-1R、VEGF-C阳性表达有关(P< 0.05)。D2-40标记的淋巴管密度（LVD）在IGF-1R、VEGF-C阳性表达组明显高于阴性组，且两者的阳性表达在研究组呈正相关。结论 IGF-1R、VEGF-C的表达与宫颈癌的淋巴转移有关，对于早期判断淋巴结转移有一定价值，联合检测二者有助于判断预后，指导临床治疗。

关键词: 宫颈鳞癌, 免疫组织化学, 胰岛素样生长因子1受体, 血管内皮生长因子C