The expression of IGF-1R, VEGF-C and its relationship with cervical cancer lymph node metastasis.
FU Gai-ling, XUE Ling-ling，ZHOU Xiao-liang.
Chinese Journal of Practical Gynecology and Obstetrics ›› 2014, Vol. 30 ›› Issue (6) : 437-440.
The expression of IGF-1R, VEGF-C and its relationship with cervical cancer lymph node metastasis.
Abstract:Objective Explore the expression of IGF-1R, VEGF-C and its relationship with cervical cancer lymph node metastasis.Methods Selected 50 cases of cervical squamous carcinoma tissues as the experimental group, 30 cases of normal cervical tissue as control group, using immunohistochemical SP method research the expression of IGF-1R, VEGF-C.Results The experimental group, lymph node metastasis was the positive expression of IGF-1R and VEGF-C ([WTBX]P[WTBZ]<0.05).Lymphatic vessel density marked by D2-40 in IGF-1R, VEGF-C positive expression group was significantly higher than negative group, and both positive expression in the experimental group were positively correlated.Conclusion The expression of IGF-1R,VEGF-C associated with cervical lymph node metastasis, lymphatic channel transfer has certain value for early judgment of cervical squamous carcinoma, joint detection both are important indicator of prognosis, and could guide clinical treatment.
cervical squamous cell carcinoma / immunohistochemical / IGF-1R / VEGF-C
[1］ Novosyadlyy R,Vijayakumar A, Lann D，et al.Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-1R is required for oncogene activation and tumor initiation[J].Oncogene,2009,28（39）:3477-3486.
[2］ Seccareccia E，Brodt P.The role of the insulin-like growth factor-1 receptor in malignancy: an update[J].Growth Horm IGF Res,2012,22(6):193-199.
[3］ Yerushalmi R，Gelmon KA ，Leung S，et al.Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes[J]. Breast Cancer Res Treat,2012,132: 131-142.
[4］ Ji RC.Lymphatic endothelial cells, lymphangiogenesis, and extracellular matrix[J].Lymph Res Biol，2006，4(2):83-100.
[5］ Chekhonin VP,Shein SA,Korchagina AA,et al.VEGF in tumor progression and targeted therapy[J]. Curr Cancer Drug Targets,2013,13(4):423-443.
[6］ Wang Z, Chen Y, Li X,et al.Expression of VEGF-C/VEGFR-3 in human laryngeal squamous cell carcinomas and its significance for lymphatic metastasis[J]. Asian Pac J Cancer Prev,2012,13(1):27-31.
[7］ Kawakami M，Yanai Y，Hala F，et al．Vascular endothelial Growth factor C promotes lymph node metastasis in a rectal cancer orthotopic model[J]．Surg Today，2005，35（2）：131-138.
[8］ 张梅娟，张丽华.免疫标记物D2-40在病理诊断中的应用和意义[J].诊断学理论与实践，2006，6（3）：277-280.
[9］ Tang Y, Zhang D, Fallavollita L，et al.Vascular endothelial growth factor C expression and lymph node matastasis are regulated by the type Ⅰinsulin-like growth factor receptor[J].Cancer Res,2003,63(6):1161-1171.
/
| 〈 |
|
〉 |
