Obstetrics and Gynecology Department，Peking Union Medical College Hospital，Peking Union Medical College，Chinese Academy of Medical Sciences，Beijing 100730，China
LIU Jun-tao，ZHOU Xi-ya.. Prenatal screening and prenatal diagnosis of aneuploidy in twin pregnancy.[J]. Acta Metallurgica Sinica, DOI: 10.7504/fk2015060108.
［1］ Rodis JF，Egan JF，Craffey A，et al. Calculated risk of chromosomal abnormalities in twin gestations［J］. Obstet Gynecol，1990，76：1037-1041. ［2］ Bush MC，Malone FD. Down syndrome screening in twins［J］. Clin Perinatol，2005，32：373-386. ［3］ Cuckle H. Down’s syndrome screening in twins［J］. J Med Screen，1998，5：3-4. ［4］ Spencer K，Nicolaides KH. Screening for trisomy 21 in twins using first trimester ultrasound and maternal serum biochemistry in a one stop clinic：a review of three-year experience［J］. Br J Obstet Gynaecol，2003，110：276-280. ［5］ Wald NJ，Rish S，Hackshaw AK. Combining nuchal translucency and serum markers in prenatal screening for Down syndrome in twin pregnancies［J］. Prenat Diagn，2003，23：588-592. ［6］ Canick JA，Kloza EM，Lambert-Messerlian GM，et al. DNA sequencing of maternal plasma to identify Down syndrome and other trisomies in multiple gestations［J］. Prenat Diagn，2012，32：730-734. ［7］ Lau TK，Jiang F，Chan MK，et al. Non-invasive prenatal screening of fetal Down syndrome by maternal plasma DNA sequencing in twin pregnancies［J］. J Matern Fetal Neonatal Med，2013，26：434-437. ［8］ Huang X，Zheng J，Chen M，et al. Noninvasive prenatal testing of trisomies 21 and 18 by massively parallel sequencing of maternal plasma DNA in twin pregnancies［J］. Prenat Diagn，2014，34：335-340. ［9］ Bevilacqua E，Gil MM，Nicolaides KH，et al. Performance of screening for aneuploidies by cell-free DNA analysis of maternal blood in twin pregnancies［J］. Ultrasound Obstet Gynecol，2015，45：61-66. ［10］ Leung TY，Qu ZZ，Liao JW，et al. Noninvasive twin zygosity assessment and aneuploidy detection by maternal plasma DNA sequencing［J］. Prenat Diagn，2013，33：675-681. ［11］ Chasen ST，Perni SC，Predanic M，et al. Does a“vanishing twin”affect first-trimester biochemistry in Down syndrome risk assessment? ［J］. Am J Obstet Gynecol，2006，195：236-239. ［12］ Spencer K，Staboulidou I，Nicolaides KH. First trimester aneuploidy screening in the presence of a vanishing twin：implications for maternal serum markers［J］. Prenat Diagn，2010，30：235-240. ［13］ Gjerris AC，Loft A，Pinborg A，et al. First-trimester screeing markers are altered in pregnancies conceived after IVF/ICSI［J］. Ultrasound Obstet Gynecol，2009，33：8-17. ［14］ Abbas A，Sebire NJ，Johnson M，et al. Maternal serum concentrations of pregnancy associated placental protein A and pregnany specific B1 glycoprotein in multifetal pregnancies before and after fetal reduction［J］. Hum Reprod，1996，11：900-902. (2015-03-25收稿)
