微量元素对妊娠期高血压疾病的预防作用

doi:10.7504/fk2014070104

摘要/Abstract

摘要：

妊娠期高血压疾病是妊娠期特有的严重产科并发症，与母胎的发病率与死亡率密切相关，主要表现为孕20周后出现水肿、高血压及蛋白尿。目前发病机制并不明确，多种因素参与其发病，许多证据支持孕妇某些营养元素的缺乏及不均衡与妊娠期高血压疾病的发生及发展相关。现就孕期不同微量元素补充对妊娠期高血压疾病的预防作用予以说明。

关键词: 微量元素, 妊娠期高血压疾病, 预防作用

Abstract:

Abstract: Hypertensive disorders of pregnancy (HDP), defined as the edema, hypertension and proteinuria appeared after 20 week of pregnancy, is a pregnancy idiopathic complications that accounts for significant maternal and fetal morbidity and mortality. Although the potential pathogenesis is not fully understood, the imbalance and insufficiency of micronutrient element is regarded as important in the occurrence and development of hypertensive disorders in pregnancy. This article reviewed the relations between trace elements and hypertensive disorders in pregnancy.

Key words: trace elements, hypertensive disorders in pregnancy, prevention

中图分类号:

R714.2

马玉燕，桑洪爱. 微量元素对妊娠期高血压疾病的预防作用[J]. 中国实用妇科与产科杂志, DOI: 10.7504/fk2014070104.

MA Yu-yan, SANG Hong-ai.. The preventive role of trace elements in hypertensive disorders in pregnancy.[J]. Acta Metallurgica Sinica, DOI: 10.7504/fk2014070104.

参考文献

［1］   Hovdenak N, Haram K. Influence of mineral and vitamin supplements on pregnancy outcome［J］. Eur J Obstet Gynecol Reprod Biol,2012,164(2):127-132.

［2］   Patrelli T S, Dall'Asta A, Gizzo S, et al. Calcium supplementation and prevention of preeclampsia: a meta-analysis［J］. J Matern Fetal Neonatal Med,2012,25(12):2570-2574.

［3］   Zerfu TA, Ayele HT. Micronutrients and pregnancy; effect of supplementation on pregnancy and pregnancy outcomes: a systematic review［J］. Nutr J,2013,12:20.

［4］   Kaushal M, Magon N. Vitamin D in pregnancy: A metabolic outlook［J］. Indian J Endocrinol Metab,2013,17(1):76-82.

［5］   Pfeifer M, Begerow B, Minne HW, et al. Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women［J］. J Clin Endocrinol Metab,2001,86(4):1633-1637.

［6］   Siddiqui IA, Jaleel A, Kadri HM, et al. Iron status parameters in preeclamptic women［J］. Arch Gynecol Obstet,2011,284(3):587-591.

［7］   Sarwar MS, Ahmed S, Ullah MS, et al. Comparative study of serum zinc, copper, manganese, and iron in preeclamptic pregnant women［J］. Biol Trace Elem Res,2013,154(1):14-20.

［8］   乐杰.妇产科学［M］.第七版.北京:人民卫生出版社,2010:97.

［9］    Rayman MP, Bode P, Redman CW. Low selenium status is associated with the occurrence of the pregnancy disease preeclampsia in women from the United Kingdom［J］. Am J Obstet Gynecol,2003,189(5):1343-1349.

［10］   Mistry HD, Wilson V, Ramsay MM, et al. Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies［J］. Hypertension,2008,52(5):881-888.

［11］   丰有吉,沈铿.妇产科学［M］.第2版.北京:人民卫生出版社,2011:83.

［12］   Enaruna NO, Ande A, Okpere EE. Clinical significance of low serum magnesium in pregnant women attending the University of Benin Teaching Hospital［J］. Niger J Clin Pract,2013,16(4):448-453.

［13］   Farzin L, Sajadi F. Comparison of serum trace element levels in patients with or without pre-eclampsia［J］. J Res Med Sci,2012,17(10):938-941.

［14］   Kim J, Kim YJ, Lee R, et al. Serum levels of zinc, calcium, and iron are associated with the risk of preeclampsia in pregnant women［J］. Nutr Res,2012,32(10):764-769.

［15］    Katz O, Paz-Tal O, Lazer T, et al. Severe pre-eclampsia is associated with abnormal trace elements concentrations in maternal and fetal blood［J］. J Matern Fetal Neonatal Med,2012,25(7):1127-1130.

［16］    Negi R, Pande D, Karki K, et al. Trace elements and antioxidant enzymes associated with oxidative stress in the pre-eclamptic/eclamptic mothers during fetal circulation［J］. Clin Nutr,2012,31(6):946-950.

［17］   Rabinowitz MB, Needleman HL. Environmental, demographic, and medical factors related to cord blood lead levels［J］. Biol Trace Elem Res,1984,6(1):57-67.

（2014-04-10收稿）

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