子痫前期中的氧化应激和抗氧化治疗

doi:10.7504/fk2014090109

摘要/Abstract

摘要：

伴随着子痫前期（PE）过度的氧化应激状态，胎盘和母体的循环系统也发生一系列的抗氧化反应，这些改变的抗氧化反应能导致脂质过氧化物增加，也能影响细胞信号转导和某些与血管活性物质合成有关的酶通路。基于上述发病机制，推测妊娠期补充抗氧化剂可能对抗氧化应激进而预防或延迟PE的发生。许多学者试验性地采用抗氧化治疗如补充维生素C、维生素E、硒元素等来预防PE的发生，但结果并不乐观，尚需大量前瞻性研究予以充实和完善。

关键词: 子痫前期, 氧化应激, 抗氧化反应, 抗氧化剂

Abstract:

Abstract: With the higher OS status, many antioxidant systems have been shown to be upregulated or downregulated in the placenta and or the maternal circulation during PE. Such altered antioxidant response can lead to increased lipid peroxidation and can also affect signal transduction and enzymatic pathways related to eicosanoid synthesis. Based on the above mechanism, antioxidants might be important for the prevention of PE. But no statistically significant difference was found between women who received antioxidant treatment and women who received placebo for preeclampsia. Further prospective study is needed in this field.

Key words: preeclampsia, oxidative stress, antioxidant response, antioxidant

中图分类号:

R714.24+4

刘俊涛，宋英娜. 子痫前期中的氧化应激和抗氧化治疗[J]. 中国实用妇科与产科杂志, DOI: 10.7504/fk2014090109.

LIU Jun-tao, SONG Ying-na.. Oxidative stress and antioxidant response in preeclampsia.[J]. Acta Metallurgica Sinica, DOI: 10.7504/fk2014090109.

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（2014-07-05收稿）

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