生殖道人乳头瘤病毒感染规范诊治

doi:10.7504/fk2014080110

摘要/Abstract

摘要：

女性生殖道人乳头瘤病毒(HPV)感染很普遍，其中多数HPV感染能自然清除。有众多的HPV检测方法，但HPV检测的主要目的是确定是否存在高级别癌前病变, 而不是诊断有无HPV感染。对生殖道低危型HPV感染的治疗以清除疣体为主，对单纯高危型HPV感染需规范管理，对生殖道高级别癌前病变应及时治疗。

关键词: 人乳头瘤病毒, 生殖道

Abstract:

Abstract:Human papillomavirus genital infection (HPV) in women is common and the majority of HPV infections will spontaneously clear. The main purpose of HPV testing is to determine whether there is a high-grade precancer, rather than a HPV infection itself, although various methods are available for HPV detection. Removal of warts is the therapeutic strategy for low-risk HPV infection of genital tract. High-grade lesions should be properly treated without delay. However, standardized management of high-risk HPV infection without precancer should be carried out.

Key words: human papillomavirus, genital tract

中图分类号:

R759

傅云峰，谢幸. 生殖道人乳头瘤病毒感染规范诊治[J]. 中国实用妇科与产科杂志, DOI: 10.7504/fk2014080110.

FU Yun-feng, XIE Xing.. Standardized diagnosis and treatment of human papillomavirus genital infection.[J]. Acta Metallurgica Sinica, DOI: 10.7504/fk2014080110.

参考文献

［1］   Bouvard V, Baan R, Straif K, et al. A review of human carcinogens--Part B: biological agents ［J］. Lancet Oncol, 2009,10(4):321-322.

［2］   Bruni L, Diaz M, Castellsagué X, et al. Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings ［J］. J Infect Dis, 2010,202(12):1789-1799.

［3］   Rositch AF, Koshiol J, Hudgens MG, et al. Patterns of persistent genital human papillomavirus infection among women worldwide: a literature review and meta-analysis ［J］. Int J Cancer, 2013,133(6):1271-1285.

［4］   Castle PE, Rodríguez AC, Burk RD, et al. Long-term persistence of prevalently detected human papillomavirus infections in the absence of detectable cervical precancer and cancer ［J］. J Infect Dis, 2011,203(6):814-822.

［5］   Bosch FX, Burchell AN, Schiffman M, et al. Epidemiology and natural history of human papillomavirus infections and type-specific implications in cervical neoplasia ［J］. Vaccine, 2008,26 (Suppl 10):k1-16.

［6］   Ikenberg H. Laboratory diagnosis of human papillomavirus infection ［J］. Curr Probl Dermatol, 2014,45:166-174.

［7］   Szarewski A, Mesher D, Cadman L, et al. Comparison of seven tests for high-grade cervical intraepithelial neoplasia in women with abnormal smears: the predictors study ［J］. J Clin Microbiol, 2012,50(6):1867-1873.

［8］   Tao K, Yang J, Yang H, et al. Comparative study of the cervista and hybrid capture methods in detecting high-risk human papillomavirus in cervical lesions ［J］. Diagn Cytopathol, 2014,42(3):213-217.

［9］   Laudadio J. Human papillomavirus detection: testing methodologies and their clinical utility in cervical cancer screening ［J］. Adv Anat Pathol,2013,20(3):158-167.

［10］   Stanley MA. Genital human papillomavirus infections: current and prospective therapies ［J］. J Gen Virol, 2012,93(Pt 4):681-691.

［11］    Fathi R, Tsoukas MM. Genital warts and other HPV infections: established and novel therapies ［J］. Clin Dermatol, 2014,32(2):299-306.

［12］   Massad LS, Einstein MH, Huh WK,et al. 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors ［J］. J Low Genit Tract Dis, 2013,17(5 Suppl 1):S1-S27.

（2014-05-16收稿）

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