关键词: 宫颈癌, 妊娠, 新辅助化疗

Abstract:

Abstract:Objective To investigate the characteristics,diagnosis,treatment and prognosis of cervical cancer in pregnancy and discuss new managements of fetal-sparing. Methods The clinical data of 7 cases with cervical cancer in pregnancy between January 2005 and March 2013 were analyzed retrospectively.Results Six patients are single pregnancy and one patient is twin pregnancy.There was 1 case ofⅠB1,5 cases of ⅠB2-ⅡA and 1 case ofⅡ B. Six patients were squamous cell carcinoma while one was adenocarcinoma. Two patients accepted the treatment with a radical hysterectomy with fetus in situ,one patient received radiation while four others desired to continue their pregnancies. Among them,one patient chose to delay the operative treatment for 8 days. Three of them were treated with cisplatin plus paclitaxel as neoadjuvant chemotherapy until fetal pulmonary maturity was achieved and then accepted a cesarean section followed by radical hysterectomy at a range of 33 to 33＋6 weeks of gestation. The median disease-free survival was 45months. All neonates were healthy and no abnormalities were found up to date.Conclusions It is necessary to make the screening of cervical lesions in prenatal examination. There are different options of treatment which can be discussed on the basis of several factors such as tumor stage,gestational age,and the patient's desire regarding fertility and pregnancy sparing. Neoadjuvant chemotherapy with paclitaxel and platinum followed by cesarean section and radical surgery is an innovative approach for selective pregnant women with invasive cervical cancer and more studies are required.

Key words: cervical cancer, pregnancy, neoadjuvant chemotherapy