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06 November 2010, Volume 25 Issue 11 Previous Issue    Next Issue

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Visfatin in IUGR：cord blood level and mRNA expression in placenta. CHEN Jie-ru*，LIU Qian-qi，CHEN Hong-min. 2010, 25(11): 854.  Abstract ( )   Objective　To explore the mechanisms of visfatin in fetal growth. Methods　From Dec.2008 to Dec.2009，the cord blood plasmaconcentrations of visfatin in 90 term neonates at birth in Wuxi Maternal and Child Health Hospital，Wuxi No.3 People’s Hospital and Wuxi Xishan Hospital was measured by Elisa and its mRNA expression by quantitative real-time PCR in placenta.The correlation between birth weight ，cord blood visfatin，and mRNA expression was analyzed. Results　Cord blood concentration of visfatin in IUGR were significantly higher than that of fetal macrosomia and healthy term infants（P < 0.05），while there was no difference between fetal macrosomia and healthy term infants（P > 0.05）.There was no difference in visfatin mRNA expression in placenta between the three subgroups. Regression analysis revealed that cord blood visfatin levels were inversely（r = -0.416，P < 0.05）correlated with birth weight，while visfatin mRNA expression was correlated with neither birth weight nor cord blood visfatin（P > 0.05）. Conclusion　Concentrations of cord blood visfatin are significantly higher in the IUGR than in the fetal macrosomia and healthy term infants，although no differences in its mRNA expression in placenta are observed.

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The characteristics in children with ADHD comorbiding anxiety and depression. GAO Wei-jia*， SU Lin-yan， DING Xiang-ping，FENG Zhe， MA Jing， Ding Jun， YANG Fan. 2010, 25(11): 857.  Abstract ( )   Objective　To estimate the occurrence of attention deficit hyperactivity disorder comorbiding anxiety and depression and to compare the behavior characteristics of ADHD with and without anxiety or depression. Methods　A total of 105 children with ADHD meeting DSM-4 diagnostic criteria aged from 8 to 14 years were involved in this study. They were evaluated with the Screen for Child Anxiety Related Emotional Disorders（SCARED）， Depression Self-Rating Scale for Children（DSRSC） by self-report and Achenbach’s Child Behavior Checklist （CBCL） by their parents. Another 66（without diagnosis of ADHD） children aged from 8-14 years who were selected from a school as a control group were evaluated too，according to SCARED and DSRSC， a  ormal group （43 children） was selected from control group for analysis.  Results　Thirty-nine of 105 children with ADHD compared to 13 of 66 controls scored at or beyond the clinical cut off （25 points） of SCARED score . Thirty-three of 105 children with ADHD compared to 10 of 66（15.2%） controls reached the threshold（15 points） of DSRSC of Chinese Norm （χ2 = 5.704，P  = 0.017）. In ADHD group 16 of 105（15.2%） ADHD children comorbid both anxiety and depression，but none in controls. In ADHD children， all scores of social ability were lower while all CBCL behavior scores were higher than normal controls except somaticcomplaint； ADHD with anxiety had higher score in somatic complaint；ADHD with depression had higher score in anxious/depressed and ADHD with both anxiety and depression had higher score in Withdrawn， somatic complaint， Anxious/Depressed， thought problems，attention problems andinternalizing problems than ADHD without anxiety and depression. Conclusion　The children with ADHD have high occurrence of comorbidity ofanxiety and depression. Children comorbided both anxiety and depression have more behavior and internalizing problems， which implies that there is a need for further mental health services for this population.

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Assessment of left ventricular torsion in children with acute leukemia receiving chemotherapy of daunorubicin using two-dimensional speckle tracking imaging. WANG Ying*， LIU Li， MAI Hui-rong，LI Chang-gang，LI Shu-na，XIA Bei. 2010, 25(11): 861.  Abstract ( )   Objective　To assess the left ventricular torsion in children with acute leukemia after induced therapy by daunorubicin（DNR）. Methods　A total of 60 healthy volunteers served as controls；60 children with acute leukemia before and after induced therapy by DNR were enrolled. All the child patients were divided into three groups according to course of therapy by DNR. Group A： patients before induced therapy by DNR； Group B： patients undergoing induced DNR with accumulated dose of 120 mg/m2； Group C： patients induced DNR with accumulated dose of 240 mg/m2. The left ventricular short-axis images at the levels of mitral annulus and apex were acquired. Using 2-dimensional strain software， the peak systolic rotations were measured in the left ventricular short-axis images and the peak systolic torsions were calculated. Results　There was no significant difference between control group and group， A，B and C in EF and E/A. In healthy volunteers， the left ventricular performed a systolic torsion， with a counterclockwise rotation at the apex and a clockwise rotation at the mitral annulus. In the children with acute leukemia receiving induced therapy by DNR with accumulated dose of 240 mg/m2， the peak systolic rotations of the level of mitral annulus and the peak systolic torsion were decreased. Conclusion　The early changes of left ventricular regional myocardial systolic function in children with acute leukemia after induced therapy by DNR with accumulated dose of 240mg/m2 can be measured by two- imensional speckle tracking imaging.

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Detection and clinical study on polyomavirus KIPyV and WUPyV in children hospitailzed for acute lower respiratory tract infections. XIAO Ni-guang*，ZHANG Bing，DUAN Zhao-jun，XIE Zhi-ping，ZHONG Li-li， GAO Han-chun，D 2010, 25(11): 865.  Abstract ( )   Objective　In order to understand the epidemiological and virologic characteristics of WU Polyomaviruses （WUPyV） and KI Polyomaviruses （KIPyV） infection in hospitalized children with acute respiratory tract infection （ARTI） in Changsha. Methods　A total of 773 nasopharyngeal aspirates （NPA） specimens were collected from hospitalized children with ARTI between September 2007 and March 2008 in Changsha. Specimens were screened for WUPyV and KIPyV by nested polymerase chain reaction. All positive amplification products were confirmed by sequencing and compared with those in GenBank. Results　Polyomaviruses were detected in 53 patients （6.8%） out of the 773 children （WUPyV was 5.0%，KIPyV was 1.8%）. The patients were from 20 days to 5 years. Similarity of WUPyV and KIPyV with those published in the GenBank at nucleotide levels was 93%～100% and 95%～100%， respectively. Conclusion　WUPyV and KIPyV may be important pathogens in children with acute lower respiratory tract infection and associated with lower respiratory diseases.

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The clinical survey and analysis of sleep habit of children with epilepsy aged from 7 to 14 years old. CAI Xiao-tang，LUO Rong，KANG Lin-min，GAN Jing，CHEN Feng. 2010, 25(11): 868.  Abstract ( )   Objective　To evaluate sleep habits and related affecting factors in children with epilepsy aged from 7 to 14 years old. Methods　By asking parents and guardians， the children's sleep habit questionnaire was used to evaluate sleep habits of 162 children with epilepsy and 162 normal controls. Results　The mean score on the sleep questionnaire for children with epilepsy was 32.4±3.6 （P < 0.01）， whereas for the normal control group it was 58.8±3.3 （P < 0.01）. In children with epilepsy， neuropsychomotor developmental delay had higher scores（49.9±7.3） than that of appropriate development （43.5±8.1，P < 0.01）. The group under polytherapy （54.3±5.7） had a higher score than that under monotherapy（42.9±6.3）. In addition， the mean score for patients with daytime seizures was 44.1±7.6，and for those with nocturnal seizures it was 52.3±5.7 （P < 0.01）. The mean score for children with partial seizures was 41.6±4.9，and for those with generalized seizures it was 47.4±8.7 （P < 0.01）. Conclusion　Children with epilepsy are prone to have sleep disorders. Many factors， such as neuropsychomotor development，seizure type，seizure frequency and therapy of seizures， can affect their sleep habits.

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Clinical analysis of 16 children infected by leishmania with hemophagocytic syndrome. LUO XIN-Hui*，Amguli，ZHANG Bin，YAO Tong，SUN He. 2010, 25(11): 871.  Abstract ( )   Objective　To investigate the clinical diagnosis treatment and prognosis of young children infected by leishmania with hemophagocytic syndrome （HPS） in Xinjiang. Methods　During December 2007and December 2009，16 patients of young children with HPS were hospitalized in the Pediatric Department of the People’s Hospital，Xinjiang Uyghur Autonomous Region. The data of patients’ habitation， clinical presentation and laboratory results were reviewed and analyzed. Results　All the 16 patients came from the Tarim Basin in Xinjiang and the diagnosis was supported by laboratory tests. In nine patients，Lidou body （Leishmania donovani） were found in bone marrow，and in fourteen patients，serum rK39-ELISA （rK39： Leishmania donovani gene expression product； ELISA： enzyme-linked immunosorbent assay） test was positive. The first two cases among these16 patients were misdiagnosed as familial HPS，who had no response to the treatment and died. The other 14 cases were diagnosed as Assam fever caused by visceral leishmania，and sodium antimony gluconate was administered. Fourteenpatients were cured. Conclusion　In the Tarim Basin，in young patients with HPS the visceral leishmania infection should first be considered. Serum rK39-ELISA test is helpful in the diagnosis of Leishmania infection. The HPS Assam fever in young children is often emergent and severe ；the children would die quickly unless an early diagnosis were made and appropriate treatment were given.

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Diagnosis and treatment of biotin deficiency：clinical study of 18 patients. WANG Hong-mei，WU Hu-sheng. 2010, 25(11): 874.  Abstract ( )   Objective　To investigate the clinical manifestation，diagnosis，and treatment of biotin deficiency. Methods　Eighteen patients with biotin deficiency were confirmed by biotin assay with immunologic method and biotinidase assay with chemoluminescence. Their clinical features，laboratory findings，and treatment regimen were reviewed. The response to the treatment of biotin was followed up. Results　（1） There were variant clinical manifestations. Among 18 cases，16 had eczematous skin rash and/or pachylosis，9 had hair abnormality，13 had mental retardation，5 had seizures，4 had frequent respiratory infection，and 2 with dysaudia. （2） Some cases had comorbidities： 2 with congenital dysplasia of eye，1 with thyroid hypofunction，and 1 with tic disorder. （3） Laboratory investigations showed biotin was from < 10 to 98 ng/L，biotinidase was normal；urinary organic acid analysis with gas chromatography/mass spectrometry （GC/MS） among 15 cases showed no evidence about multiple carboxylase deficiency. Gesell Test Score was from 29 to 81 in 9 cases，normal in 4 cases. Some cases had nonspecific abnormal image in the brain，abnormal electroencephalogram，and dysaudi，etc. （4） All patients were supplemented with biotine individually （10～40 mg/d）. Mental state，appetite，dermatological and hair manifestations of this group were remarkable improved. Conclusion　The clinical manifestations of biotin deficiency are complicated. Dermatological and/or hair manifestations are the main features and diagnostic clue. There is remarkable response to the biotin treatment. It is important to improve the knowledge of comorbidity. Early diagnosis and biotin supplementation can contribute significantly to the improvement of prognosis.

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Study on the relationship between the serum ferritin levels and disease activity in children with systemic lupus erythematosus. LIU Yang，YE Chun-feng ，LIU Yan-ling，FANG Xiang-dong. 2010, 25(11): 877.  Abstract ( )   Objective　To investigate the changes and clinical significance of serum ferritin（SF）levels in children with systemic lupus erythematosus（SLE）. Methods　The serum ferritin levels of 58 children with SLE were measured by Chemiluminescence before and after treatment，and serum ferritin levels were measured in 30 normal children. Results　The serum ferritin levels were significantly higher in children with SLE than those in healthy controls as well as in active children than in inactive children with SLE.And the serum ferritin leveis were significantly decreased after treatment，Moreover， the serum levels of ferritin were positively correlated with anti-ds-DNA antibody levels and SLEDAI（SLE Disease Activity Index）in children with SLE. Conclusion　The serum ferritin levels in children with SLE are significantly higher than those in normal children. Serum ferritin levels aree positively correlated with disease activity in children with SLE.Therefore serum ferritin levers can be a useful laboratory marker to diagnose SLE in children.