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06 January 2009, Volume 24 Issue 01 Previous Issue    Next Issue
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Determination and seroconversion of hepatitis B markers in the newborn of hepatitis B virus carrier mothers. XIAO Xiao-min，LI Ai-zhen，LIU Dong-yang，MENG Qing-ju,CHEN Xin,XU Yu-yuan,DONG Ai-zhi. 2009, 24(01): 31-33 .  Abstract ( )   ObjectiveTo explore the seroconversion of hepatitis B markers in the neonates born to hepatitis B carrier women.MethodsA total of 500 neonates born to the women positive for hepatitis B surface antigens (HBsAg)were recruited.Depending on the hepatitis B e-antigens(HBeAg)status of their mothers，they were divided into two groups.Group A had 144 cases,the serum HBeAg of their mother was positive,and Group B had 356 cases,the serum HBeAg being negative.All neonates received 100IU HBIG within 12 h of birth and followed by 3 doses 5μg hepatitis B vaccination at birth and at the age of one and six months schedule.The hepatitis B serologic markers of infants were followed up at birth and at the age of one and six months.ResultsThere were 24 and 9 neonates in group A and B respectively with serum HBsAg(+)and HBeAg(+)at birth.After six months of follow-up,there were 10 cases in Group A and 5 cases in Group B with HBsAg positive constantly.There were no significant difference between Group A and B in the HbsAg conversion rate,4 and 21 neonates in Group A and B respectively with serum HBsAg(+)and HBeAg(-)at birth.Of them，the seroconversion rate to HBsAg negativity was 100% and 85.7% in Group A and B respectively at six months visit.No significant difference was found between two groups.There were 29 infants in Group A tested HBsAg(-)/HBeAg(+)at birth，it was significantly higher than the rate of Group B(29/144 vs 3/356)，P<0.01.Of them，the neonatal seroconversion rate to HBsAg positivity at six months of age was 6.9% and 100% respectively in Group A and B，the difference being significant between two groups，P=0.037.There were 87 infants in Group A and 323 infants in Group B tested HBsAg(-)/HBeAg(-)at birth.Of them 2 cases and no cases in Group A and B tested positive for HBsAg at the 6-month visit.No significant difference was found in their seroconversion rate to HBsAg positive.ConclusionNeonates would not be diagnosed as intrauterine infection of HBV when their serum HBsAg was positive at birth.The prognosis of neonates with HBeAg-positive at birth correlats with their maternal HBeAg status.

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Study on Beta3-adrenergic receptor gene polymorphism in Karzak obese children in xinjiang. ZHANG Ji-hong,XU Pei-ru,LI Li,CHANG Zhong-sheng. 2009, 24(01): 34-36 .  Abstract ( )   ObjectiveTo investigate the association between Trp64Arg mutation of theβ3-adrenergic-receptor gene and obesity in Karzak children.MethodsTotally 95 patients with obesity and 87 controls were selected from the area around Urumqi.Genotype of the β3-AR was determined by polymerase chain reaction(PCR)and restriction fragment length polymorphism methods (RFLP).Polymorphism(PCR RFLP)and serum concentration of triglyceride,total cholesterol,low density lipoprotein cholesterol (LDL-C),apolipoprotein A(ApoAI),apolipoprotein B(ApoB) and high density lipoprotein cholesterol (HDL-C) were measured with biochemical method.In the mean time,the weight and height were detected.ResultsThe mutative Callee was 0.194 for all the children,0.210 for boys and 0.160 for girls.The frequency of callee and the genotype Trp64Arg was higher in obese children.There were higher levels of the lipids in Karzak obese children than in the control group,excluding apolipoprotein A and high density lipoprotein cholesterol.There was no apparent difference between the genotype Trp64Arg and Trp64Trp in serum concentration of lipids.ConclusionThere is distribution of β3-AR Trp64Arg mutation in Karzak school-aged children in XinJiang.These results suggest that the Trp64Arg mutation of β3-adrenergic-receptor gene may be associated with Karzak children obesity.

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Analysis of 63 cases of kawasaki disease complicated with coronary aneurysms. DUAN Chao,DU Zhong-dong. 2009, 24(01): 37-40 .  Abstract ( )   ObjectiveTo investigate the clinical characteristics and prognosis of coronary aneurysm in children with Kawasaki disease.MethodsCoronary aneurysm was identified by using echocardiography in 63 children with Kawasaki disease from 2000 to 2007.Their gender,age,clinical presentations,use of intravenous gamma immunoglobulin (IVIG),laboratory study results and echocardiographic study results in the acute and convalescent phase were examined retrospectively.Results(1) Boys and infants were more likely to develop coronary aneurysms,the male to female ratio being 5.3∶1,and for patients with giant aneurysms the male to female ratio was 8.3∶1.(2)The rate of incomplete KD,IVIG non-responders and recurrence in this group of patients were 36.5%,30.2% and 7.9%,respectively,which were higher than the whole KD group.In the acute phase,57 of 63 patients were treated by IVIG with different doses,3 of them did not receive IVIG treatment and the other 3 patients’ IVIG treatments were unknown.The duration from onset to IVIG treatment was longer than 10 days in 36 of the 63 (57.1%) children.(3) Small aneurysms were detected by 2-D echo in 7 patients,medium aneurysms in 19 patients and giant aneurysm in 37 patients.In all of these patients,76.2% of them had left coronary artery aneurysms,and 87.3% of them had right coronary artery aneurysms;47.3% of them had both left and right aneurysms.In the patients with left coronary aneurysms,58.3% of them have left anterior descending branch aneurysms; and in patients with right coronary aneurysms,47.3% of them were located in the right coronary artery segment II.(4) Coronary aneurysm regressed in 71.4 % of the branches.The lumen diameter of the affected branches returned to normal in 45.2% of them,with a mean regression time of 2.1±1.5 years.ConclusionBeing male,younger than 1 year old,incomplete KD,IVIG non-responder,recurrence and later IVIG treatment are possible risk factors of coronary aneurysms in children with Kawasaki disease.Most children have multi-coronary artery aneurysms and left anterior descending branch and right coronary artery are the most commonly affected branches，and most of the coronary aneurysms have the tendency to regress during the convalescent phase.

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Growth charts for Chinese children’s height of five cities allowing for height of parents. ZHANG Shao-yan,ZHANG Ji-ye,LIU Gang,HAN Yi-san,MA Zhen-guo,SHEN Xun-zhang,XU Rui-long. 2009, 24(01): 41-45 .  Abstract ( )   ObjectiveThe correlations between heights of children and mid-parental height(MPH),and the average of two parent’s height were investigated and the growth charts of Chinese children’s height allowing for height of parents were presented.MethodsThe subjects were 13401(boys 6868,girls 6533)normal children aged 2~16 years,from middle and upper socio-economic classes of five cities in the south and north of China.The height centile curves of children were smoothing by BCPE model.The equations between child height SDS and MPH were fitted by linear regression.ResultsThe correlations between heights of children and mid-parental height(MPH)are between 0.43 and 0.55 before adolescence,and in adolescence this holds generally for pairs of variables when the children were grouped based on skeletal ages.Hence,the regressive equations between child height SDS and MPH were fitted for the subsections of 2~9 years,skeletal age 10~16 in boys and 10~15 in girls,respectively.ConclusionThe growth charts of Chinese children’s height allowing for height of parents are useful in differential diagnosis of short children,especially in genetic small stature.

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Prospective,randomized and comparative study on the sibelium and valproate prophylactic treatments for children with migraine. CAI Yi-ming,ZHOU Shui-zhen,ZHANG Lin-mei. 2009, 24(01): 46-49 .  Abstract ( )   ObjectiveTo assess the efficacy of pharmacological prophylactic treatments for migraine in children,and to study an appropriate and safe therapy benefitial to pediatric migrainuer.MethodsPedsQl 4.0 and headache index were used to assess the effect of Sibelium (Flunarizine) and valproate (VPA) after provided to the children with migraine.The two groups of 200 moderate migrainuers were compared in a prospective,randomized,controlled and open-label trial.ResultsWith the aspect of comparision between sibelium and VPA,both showed effects on increasing the quality of life of children with migraine.Total score of with Sibelium increased from 68.27±11.06 to 82.07±5.36,while the group with VPA increased from (71.82±9.03) to (82.74±5.36).Each group P<0.05,within group P>0.05.The two pharmacological ways were also effective to decrease the index of headache.The group with Sibelium decrease from (10.45±7.25) to (2.20±2.75); the group with VPA decreased from (9.81±7.58) to (2.03±2.50)，Each group P<0.05,within group P>0.05.Comparing the two groups,there were no significance about quality of life and headache index.ConclusionChildren with migraine benefit from appropriate prophylactic therapy.Sibelium and VPA could also be used for children with migraine.

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Effects of large first dose pulmonary surfactant on treatment of severe hyaline membrane disease in neurates. YANG Jie,LI Wen-cheng,YE Xiu-zhen,GAO Wei-wei,NIE Chuan. 2009, 24(01): 50-52 .  Abstract ( )   ObjectiveTo investigate the effect of large first dose of pulmonary surfactant on treatment of severe hyaline membrane disease (HMD) in neurates.MethodsFourty-eight preterm newborns with Ⅲ~Ⅳ degree HMD were randomly allocated into experimental and control groups: the large first dose group was administered surfactant (150~200) mg/kg and the small first dose group(50~100) mg/kg.Times of administration,total dosage,blood gas analysis,PaO2/FiO2,duration of mechanical ventilation and length of stay in NICU were compared between two groups.ResultsThe duration of ventilation,duration of oxygen therapy,length of stay in NICU and incidence of bronchopulmonary dysplasia in the large first dose group were less than that in small dose group.ConclusionEffects of large first dose of surfactant (200 mL/kg) are better than small first dose (100 mg/kg) on the treatment of severe HMD.

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Study on brain injury and rehabilitation care of newborns with congenital cytomegalovirus infection HU Jin-tao，CHEN Ping-yang,XIE Zong-de. 2009, 24(01): 53-55 .  Abstract ( )   ObjectiveTo investigate the abnormal appearance of nervous systerm in the newborns with congenital cytomegalovirus infection.To explore the relations between congenital cytomegalovirus infection and brain injury.MethodsA total of 81 cases with CMV infection received Ganciclovir therapy and adjunct examinations including neonatal behavioral neurological assessment and head CT or MRI and hearing examinations.Some newborns received rehabilitation care.ResultsThirty-four (43.03%)newborns had abnormal NBNA score.NBNA score could be raised after rehabilitation care.Thirty-one(46.27%)newborns had abnormal head imaging appearances such as encephalic necrosis and encephalic hypoplasia，intracranial hemorrhage and intracranial calcification and hydrocephalus.Thirty-seven(50.68%)newborns didn’t pass the first hearing test.Four babies had hearing disorder.ConclusionThe brain injuries following congenital cytomegalovirus infection are common.Adjunct examinations should be performed early and intervention treatment should be done in time to improve the prognosis of newborns.

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Pseudohypoparathyroidism of 4 cases and review of literature. WANG Shu-Lan,ZHANG Jing,HU Wan-Ru. 2009, 24(01): 56-58 .  Abstract ( )   ObjectiveTo improve the level of recognization,diagnosis and treatment of pseudohypoparathyroidism (PHP).MethodsFour patients were selected,aged between 11 ~ 14 years old,3 boys and 1 girl,chief complaints with numbness of four limbs or discontious convulsion.Measured the blood calcium，serum inorganic phosphorus,serum parathyroid hormone (PTH) and reply slip of head CT for analysis.ResultsTwo cases had typical facies and stature of PHP,the other 2 cases manifested normal phenotype,and the blood calcium decreased,while serum inorganic phosphorus and the PTH increased in all 4 patients.The treatment of calcium complement didn’t make any effect on the 4 patients.ConclusionPHP is a disease of abnormal PTH receptor.The patients of PHP are not often encountered.When the patients have the syndrome of numbness in four limbs or repetitious convulsion and the blood calcium decreases,we should consider PHP.So blood calcium decrease，serum inorganic phosphorus increase,and the PTH increase are the necessary factors of diagnosing PHP.