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06 February 2009, Volume 24 Issue 02 Previous Issue    Next Issue
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Assessment of intraventricular synchrony in children with endocardial fibroelastosis using tissue synchronization imaging. LI Lei，ZHONG Jia-rong，BAI Yong-hong，JI Xiao-juan，WANG Ya. 2009, 24(02): 109-111 .  Abstract ( )   Objective　To evaluate the intra ventricular synchrony in patients with endocardial fibroelastosis with TSI. Methods　Echocardiography and tissue synchronization imaging were performed in 36 subjects：20 served as normal controls and 16 patients had endocardial fibroelastosis. They were followed up after 6 months of treatment. Tissue synchronization imaging was performed in apical view. The time to peak myocardial systolic contraction（TS）and early diastolic relaxation（TE）were measured，and the standard deviation of TS and TE of the 12 LV segments were computed，i. e. TS-SD and TE-SD. Results　（1）The standard deviation of the time to peak myocardial systolic contraction（TS） of the study group before the treatment was higher than that of the control group，and there was statistical significance. The standard deviation of the time to peak of pre-treatment was higher than that of post-treatment and there was statistical significance；（2）The standard deviation of the time to peak myocardial early diastolic relaxation （TE） of the study group before the treatment was higher than that of the control group，and there was statistical significance. There was no statistical significance in the standard deviation of the time to peak for pre-treatment and post-treatment；（3）Left ventricular systolic function of the study group was significantly lower than that of the control group，and the study group obtained a significant recovery after treatment. Conclusion　There are significant intraventricular dyssynchrony in children with endocardial fibroelastosis，but mainly at systolic contraction. TSI can feasibly and reliably assess the intraventricular synchronicity in systole and diastole.

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Epidemiology and etiology of chronic diarrhea diseases in children. XU Xi-wei，WANG Guo-li，QIU Xiao-hong，WANG Da-yong，SHEN Hui-qing，GAO Ping-zhi，WANG Hui-ling，ZHANG Jing. 2009, 24(02): 112-115 .  Abstract ( )   To explore the epidemiology and etiology of chronic diarrhea diseases（CDD）in children， and understand the incidence， etiology and clinical manifestation. Methods　Clinical data of 179 cases of CDD hospitalized between January 1996 and January 2006 were retrospectively reviewed. Results　Morbidity of CDD was 4. 8% during these 10 years，among which 50. 3% were less than 1-year- old infants ， and 62.2% were less than 3-year-old children. Common complications included anemia（46. 4%） ，malnutrition（45. 3%）， growth and development retardation（24. 0%）， hypoalbuminemia（36. 3%）， etc. Totally 154 cases had been found with clear etiology， and final diagnosis rate was 87. 7%. The first 3 causes were inflammatory bowel diseases（IBD） （35. 2%）， infectious diseases（ 17.3%） and immunodeficiency diseases （15. 6%）. Unknown pathology （including refractory diarrhea 7 cases） occupied 12. 3%. Conclusion　Infant and young children， especially the infants often suffer from CDD， and are easily complicated with malnutrition， etc. Etiology of CDD is various，and the most common one is non-infectious diseases. IBD is the most important reason of children CDD.

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Relationship between simple obesity and fibrinogen Bβ-148C/T gene polymorphism in children. GAO Jie,ZANG Qiang,ZHAO Feng-zhen，ZHANG Jun-ling，LI Hong-fen. 2009, 24(02): 116-118 .  Abstract ( )   Objective To study the change of plasma fibrinogen level and the molecular activity of fibrinogen in children with simple obesity. To explor the relationship between the simple obesity and fibrinogen Bβ-148C/T gene polymorphism in children and to provide basis for children's simple obesity prevention. Methods A total of 106 children with simple obesity and 106 normal weight children were selected in the Affiliated Hospital of North China Coal Medical College from June 2004 to September 2007.5 mL fast blood sample was taken from each patient. Plasma fibrinogen level and molecular reactivity were measured with Assist Plasm Fibrinogen Activity Assay System. Polymerize chain reaction and restriction enzyme digestion were used to detect the fibrinogen Bβ-148C/T gene polymorphism genes genotype. Results　The plasma fibrinogen level and the molecular activity of the children with simple obesity were significantly higher than that of the health control group （P < 0.05）. The allele frequency in the children with simple obesity was higher than that of the health control group（P < 0.05）. The plasma fibrinogen level and the fibrin monomer polymerize velocity of theBβ-148 TT+CT was higher than that of the CC type in the children with simple obesity. Conclusion　The simple obesity in children is associated with the high level and the strengthen molecular activity of fibrinogen. The fibrinogen Bβ-148C/T gene polymorphism may be an accumulative efficiency gene of children with simple obesity by influencing the level and the fibrinogen metamer polymerization velocity.

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Value of angiocardiography in the stratification diagnosis of congenital heart disease. JIANG Rong,ZHAO Sheng,WANG Ze-long,WANG Jian,YU Dong. 2009, 24(02): 122-125 .  Abstract ( )   Objective　To evaluate the value of angiocadiography （ACG） in the diagnosis and treatment of complicated and/or complex congenital heart disease （CHD）. Methods　Analyze 34 cases of ACG for complicated and/or complex CHD， and compare with the results obtained by means of echocardiography （ Echo）. Results　The accordance rate by means of Echo and angiocardiography with cardiovascular operation was 71.43% （ 15/21 ） and 100%（21/21） respectively. After χ2 examination， P <0.01. Conclusion　In the field of diagnosis and differential diagnosis of knotty cases of complex and complicated CHD， the result of ACG （including DSA） is superior to Echo， and ACG examination before operation is important and indispensable.

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The influence on the simple obese children’s renal function by the joint intervention of exercise， diet and education. LI Wen-ci，ZHANG Yu，SHAO Shan-ying,PAN Tian-hong ，Huang Xiao-cheng. 2009, 24(02): 126-128 .  Abstract ( )   Objective To discuss the influence on the simple obese children’s renal function by the joint intervention of exercise， diet and education. Methods Mensurate respectively the renal function of 50 cases of simple obese children by simple diet control before and after treatment and 52 cases of simple obese children based on the control of diet and setting down a planned exercise and health education before and after treatment. Then compare the different effect accordingly. Results Compare the simple treatment group before treatment， joint intervention group before treatment with control group： Alb， IgG， TRF were higher than the controls and the differences were significant （ P <0.01）. There was no significant difference （P >0.05） in each index between simple treatment group before treatment and joint intervention group before treatment. Compare simple treatment group before treatment with after treatment： Alb， IgG， TRF differences were significant （P <0.01）. Compare joint intervention group before treatment with after treatment： Alb， IgG， TRF differences were significant （P <0.01）. Compare the simple treatment group after treatment， joint intervention group after treatment with control group： there was much significant difference （P <0.01）in each index in simple treatment group after treatment. There was no significant difference （P >0.05） in each index in joint intervention group after treatment. Conclusion The simple obese children’s renal function can be improved by the joint intervention of exercise， diet and health education. It has a positive effect on improving sufferers’ life quality in the future.

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Study on extrauterine growth restriction of premature neonates in NICU. HU Jin-tao，XIE Zong-de，CHEN Ping-yang. 2009, 24(02): 129-131 .  Abstract ( )   Objective　To study the incidence of extrauterine growth restriction （EUGR）on premature neonates in NICU， to investigate the factors correlating with EUGR. Methods　Monitor the weights of 94 premature neonates in NICU，and compare it with the standard percentiles； the complications were statisticed， and logistic regression analysis was applied to investigate the high-risk factors. Results　The incidence of intrauterine growth restriction （IUGR）was 35.1％， and the incidence of EUGR among 94 premature neonates was 72.3％， the incidence of EUGR being higher than IUGR. The results of logistic regression analysis indicated that alimentary tract hemorrhage，infection and parenteral nutrition were the high-risk factors. Conclusion　The incidence of EUGR in preterm neonates is high. To prevent the common complications of preterm neonates parenteral nutrition should be applied to conduce the decrease of EUGR.

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Clinical investigation of 135 primary immunodeficiency disorders in children. ZHAN Yu-zhu，JIANG Li-ping，ZHOU Yu，XIE Na，YANG Xi-qiang. 2009, 24(02): 132-134 .  Abstract ( )   Objective　To analyze the occurrence and diagnosis of the primary immunodeficiency disorders in children，and to promote the pediatrician to understand more about these disorders. Methods　Overview the clinical data of the 135 children with primary immunodeficiency disorders diagnosed in our hospital from May 1993 to December 2007，including the symptom，physical sign，age of onset，family history and results of immunologic test. Results　In the 135 children with primary immunodeficiency disorders，antibody deficiencies were the most frequent （34. 8%），followed by phagocyte deficiencies（18.5%），other well defined immunodeficiency syndromes（14.8%），combined T- and B-cell immunodeficiencies （11.9%），disease of immune dysregulation （5.9%），complement deficiencies （0.7%） and other primary immunodeficiencies （13.3%）. The ratio of boys to girls was 110 to 25， and clinical diagnosis to genetically diagnosis was 98 to 37. Nine cases were diagnosed in 1993 to 1996，23 cases in 1997 to 2000，31 cases in 2001 to 2003 and 7 cases were genetically diagnosed，72 cases in 2004 to 2006 and 30 cases were genetic diagnosed. Conclusion　The primary immunodeficiency disorders are inherited diseases which mainly occur in children. They are the substantial cause of recurrent，severe and deadly infection in children. It seems to be a tendency that the incidence increases with time. Genetic analysis becomes an important diagnostic technique for PID.