Abstract: Objective    To investigate the 6-month efficacy，safety and tolerability of adjunctive perampanel in children with epilepsy and compare those differences in older（≥7）and younger（<7）age groups. Methods    Children who were diagnosed with epilepsy and treated with perampanel in Wuhan Chlidren’s Hospital from June 2020 to January 2022 were included in this retrospective study.Effectiveness，safety and tolerability of perampanel between different age goups at 6 months were compared.The single or multivariate logistic regression analysis were used to analyze baseline factors affecting efficacy in duration of epilepsy，number of ASMs，final daily dose of perampanel，baseline seizure frequency and structural etiology. Results    A total of 128 children were enrolled.99 children still were treated with perampanel at 6 months， The retention rate were 77.3%（99/128），and 50% responder rate and seizure freedom rate were 47.6（61/128） and 20.3%（26/128）. No significant differences in effectiveness were found between two age groups. Adverse events were 22.7%（29/128）. No correlation was found between the efficacy and intellectual disability，duration of epilepsy，number of ASMs，final daily dose of perampanel，baseline seizure frequency and structural etiology. Conclusion    Perampanel was efficacious and generally well-tolerated as an add-on treatment for children.No differences were found between age group and no effectiveness-related factors were found.

Key words: perampanel, adjunctive therapy, epilepsy, child

摘要： 目的    观察癫痫患儿吡仑帕奈添加治疗6个月时总体疗效、保留率及安全性并比较不同年龄差异。方法    回顾性分析2020年6月至2022年1月华中科技大学同济医学院附属武汉儿童医院神经内科确诊癫痫并行吡仑帕奈添加治疗患儿。比较添加治疗6个月时低年龄组（<7岁组）及高年龄组（≥7岁组）在疗效、保留率及安全性差异。以6个月治疗有效率为因变量，以发育迟滞、癫痫病程、抗癫痫发作药物数量、维持剂量、发作频率及病因等为自变量进行单因素及多因素Logistic回归分析。结果    共128例癫痫患儿符合入组标准，6个月仍予吡仑帕奈添加治疗99例，总体有效率47.6%（61/128），无发作率20.3%（26/128），保留率77.3%（99/128）。（<7岁组）及高年龄组（≥7岁组）在6个月疗效、保留率及安全性差异无统计学意义（P>0.05）；总体不良事件发生率22.7%（29/128）；未发现影响吡仑帕奈疗效相关因素。结论    吡仑帕奈治疗癫痫患儿具有良好疗效、耐受性及安全性，不同年龄组间未见疗效差异，且未发现影响疗效相关因素。

关键词: 吡仑帕奈, 添加治疗, 癫痫, 儿童