Abstract: Bronchopulmonary dysplasia（BPD） is a complication that frequently occurs in preterm infants and is linked to the barrier structure and malfunction of the pulmonary epithelium. Claudins，known as a family of proteins，are one of the major components of tight junctions（TJs） and participate in relating intercellular exchange. Although little is known about the role of Claudin-7 in influencing alveolar barrier function and its regulation mechanism in the lung，there is evidence that expression of Claudin-7 can affect alveolar epithelial permeability and alveolar development，which in turn affects the development of BPD. The expression of Claudin-7 is affected by multiple regulatory factors，and understanding its effect will help to clarify the pathogenesis of BPD，and then open up new options for the diagnosis and the treatment of BPD.

Key words: bronchopulmonary dysplasia, Claudin-7, tight junction, preterm infant

摘要： 支气管肺发育不良（bronchopulmonary dysplasia，BPD）是早产儿常见的并发症，与肺泡上皮屏障结构和功能失调有关。Claudin蛋白家族是紧密连接（tight junctions，TJs）的主要结构之一，参与调节细胞间物质交换。尽管关于Claudin-7蛋白在影响肺泡屏障功能及在肺部的调节机制所知甚少，但Claudin-7蛋白的表达可以影响肺上皮通透性和肺泡发育，进而影响BPD发生发展。Claudin-7蛋白的表达受到多种因子的调节，了解其影响可进一步明确BPD的发病机制并为BPD的诊疗提供新方案。

关键词: 支气管肺发育不良, Claudin-7蛋白, 紧密连接, 早产儿