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A clinical observation for the efficacy and safety of levetiracetam in treatment of children with epilepsy.

LIU Zhi-shengWANG Fang-linHU Jia-sheng.   

  1. Department of Neurology, Wuhan Children’s Hospital, Wuhan 430016, China
  • Received:2008-09-20 Revised:2009-02-04 Online:2009-03-06 Published:2009-03-06

左乙拉西坦治疗小儿癫痫的疗效和安全性分析

刘智胜王芳琳胡家胜   

  1. 武汉市儿童医院神经内科,武汉 430016

Abstract: Objective To evaluate the therapeutic effect and safety of levetiracetam (Keppra). Methods A total of 56 children with epilepsy between the ages of 5 months and 14 years were treated with levetiracetam. There were 32 cases by monotherapy and 24 cases by add-on therapy. The starting dosage of levetiracetam was [5.2~20.8 mg/kg] of tablet per day twice daily, and its objective dosage was [14.4~41.6 mg/kg] per day twice daily in children with epilepsy. The follow-up period ranged from 3 to 12 months. Results  The effective rate (> or = 50% reduction in seizures) was found in 68.8%, with 40.6% achieving seizure freedom in monotherapy of levetiracetam. The effective rate was found in 41.7%, with 8.3% achieving seizure freedom in add-on therapy of levetiracetam. The effective rate of monotherapy of levetiracetam showed significant difference as compared with add-on therapy (P<0.05). There were mild adverse reactions in levetiracetam treatment of children with epilepsy, including gastrointestinal dysfunction, dizziness, somnolence and irritability, etc. Conclusion The levetiracetam is effective as monotherapy and as add-on therapy, and well tolerated for epilepsy in children. The efficacy of monotherapy is higher than that of add-on therapy in levetiracetam treatment of children with epilepsy.

Key words: child , levetiracetam

摘要: 评价左乙拉西坦(LEV)治疗小儿癫痫的疗效和安全性。方法 2007年8月至2008年8月武汉市儿童医院神经内科病房和门诊收治的56例癫痫患儿口服 LEV片。其中32例单药治疗;24例添加治疗,即在原有抗癫痫药物剂量及用法不变的基础上添加LEV口服。起始剂量为5.2~20.8 mg/(kg·d),2次/d;目标剂量 为14.4~41.6 mg/(kg·d),2次/d。随访时间为3~12个月。结果 LEV单药治疗有效率为68.8%,无发作率为40.6%,添加治疗有效率为41.7%,无发作率为8.3% 。两组比较差异有统计学意义(P<0.05)。LEV副反应较少,主要为胃肠不适、头晕、嗜睡、易激惹等。结论 LEV治疗儿童癫痫有效,单药治疗疗效高于添加治 疗,患儿对其有较好的耐受性。

关键词: 癫痫, 左乙拉西坦, 儿童