Abstract: Objective　To evaluate the therapeutic effect and safety of levetiracetam （Keppra）. Methods　A total of 56 children with epilepsy between the ages of 5 months and 14 years were treated with levetiracetam. There were 32 cases by monotherapy and 24 cases by add-on therapy. The starting dosage of levetiracetam was [5.2～20.8 mg/kg] of tablet per day twice daily， and its objective dosage was [14.4～41.6 mg/kg] per day twice daily in children with epilepsy. The follow-up period ranged from 3 to 12 months. Results 　The effective rate （> or = 50% reduction in seizures） was found in 68.8%， with 40.6% achieving seizure freedom in monotherapy of levetiracetam. The effective rate was found in 41.7%， with 8.3% achieving seizure freedom in add-on therapy of levetiracetam. The effective rate of monotherapy of levetiracetam showed significant difference as compared with add-on therapy （P＜0.05）. There were mild adverse reactions in levetiracetam treatment of children with epilepsy， including gastrointestinal dysfunction， dizziness， somnolence and irritability， etc. Conclusion　The levetiracetam is effective as monotherapy and as add-on therapy， and well tolerated for epilepsy in children. The efficacy of monotherapy is higher than that of add-on therapy in levetiracetam treatment of children with epilepsy.

Key words: child , levetiracetam

摘要： 评价左乙拉西坦（LEV）治疗小儿癫痫的疗效和安全性。方法　2007年8月至2008年8月武汉市儿童医院神经内科病房和门诊收治的56例癫痫患儿口服 LEV片。其中32例单药治疗；24例添加治疗，即在原有抗癫痫药物剂量及用法不变的基础上添加LEV口服。起始剂量为5.2～20.8 mg/（kg·d），2次/d；目标剂量 为14.4～41.6 mg/（kg·d），2次/d。随访时间为3～12个月。结果　LEV单药治疗有效率为68.8%，无发作率为40.6%，添加治疗有效率为41.7%，无发作率为8.3% 。两组比较差异有统计学意义（P＜0.05）。LEV副反应较少，主要为胃肠不适、头晕、嗜睡、易激惹等。结论　LEV治疗儿童癫痫有效，单药治疗疗效高于添加治 疗，患儿对其有较好的耐受性。

关键词: 癫痫, 左乙拉西坦, 儿童