Abstract: Wheat-dependent，exercise-induced anaphylaxis（WDEIA）is an immunoglobulin E（IgE）-mediated disease which is characterized by systemic allergic reactions triggered by synergistic factors such as exercise after wheat ingestion.It is characterized by sudden onset，high risk，and easy misdiagnosis.The clinical manifestations mainly involve the skin and respiratory and cardiovascular systems.In older children，severe cases are more common，but due to non-specific symptoms，it is often misdiagnosed.Accurate diagnosis depends on a detailed medical history，skin prick tests（especially fresh food prick tests），specific IgE（sIgE）detection，and confirmation by exercise-food combined challenge tests when necessary.The management of WDEIA in acute stage focuses on the timely use of adrenaline，while long-term strategies include avoiding high-risk factors，individualized dietary adjustments，and exploring immunotherapy，such as omalizumab and sublingual immunotherapy.Given the particularities of children’s behavior and lifestyle，the collaborative management involving families，schools，and medical teams is crucial for preventing attacks and improving the quality of life.In the future，further promotion of standardized diagnostic procedures and long-term intervention studies is needed to achieve precise prevention and control of WDEIA in children.

Key words: wheat-dependent, exercise-induced anaphylaxis, child, skin prick test, specific IgE, oral food challenge test

摘要： 小麦依赖 - 运动诱发严重过敏反应（wheatdependent，exercise-induced anaphylaxis，WDEIA）是一种以摄入小麦后在运动等协同因素作用下引发全身性过敏反应为特征的免疫球蛋白 E（immunoglobulin E，IgE）介导疾病，具有起病急、风险高、易误诊的特点。临床表现以皮肤、呼吸及心血管系统受累为主，尤其在年长儿童中更多表现为重症，但因症状非特异，常被误诊。准确诊断依赖于详尽的病史、皮肤点刺试验（尤其是新鲜食物点刺法）、特异性 IgE（specific immunoglobulin E，sIgE）检测，并在必要时通过运动 - 食物联合激发试验确认。WDEIA 的急性期管理强调及时使用肾上腺素，而长期策略则包括规避高危因素、个体化饮食调整及探索免疫治疗，如奥马珠单抗和舌下免疫疗法。鉴于儿童行为与生活方式的特殊性，家庭、学校及医疗团队的协同管理对预防发作、提升生活质量至关重要。未来需进一步推动标准化诊断流程和长期干预研究，以实现儿童 WDEIA 的精准防控。

关键词: 小麦依赖 - 运动诱发严重过敏反应, 儿童, 皮肤点刺试验, 特异性 IgE, 口服食物激发试验