Abstract:

Objective    To investigate relationship between childhood asthma control test（C-ACT）and lung function.Methods    During the clinic visit，273 asthma patients completed the Chinese version of C-ACT and underwent spirometric measurments at the same time.The correlation between C-ACT with FEV1% and PEF% were analyzed.The patients were categorized into 4 groups based on the degree of airway responsiveness（AR）， 1）severe group（PC20=0.5mg/mL）， 2） moderate group （PC20= 2mg/mL）， 3） mild group（PC20=8mg/mL）， 4） minimal group（PC20=16mg/mL），and then the relationships between C-ACT score and AR as well as ventilation function of each group were assessed by one-way ANOVA.Results     Significant correlation was observed between C-ACT score and FEV1%（r = 0.25；P＜0.01） ，PEF%（r = 0.34；P＜0.01）.When the patients less than 7 years or suffering upper respiratory tract infection（URI） 4 weeks before seeing the doctor were excluded，C-ACT score demonstrated good correlations with PEF%（r = 0.52；P＜0.01） and moderate correlations with FEV1%（r = 0.42；P＜0.01）. C-ACT score difference had statistical significance between severe group and minimal group （mean ［SD］：21.7 ［2.4］ vs.23.6 ［2.5］； P＜0.01） ，but no significant difference between moderate group and mild group.Conclusions     There is moderate correlations between C-ACT score and ventilation function and AR，and being less than 7 years or suffering URI 4 weeks before seeing the doctor may be two factors that influence this relationship.

Key words: asthma, childhood asthma control test, lung function, airway responsiveness

摘要：

目的    探究儿童哮喘控制测试（C-ACT）评分与哮喘患儿肺功能及气道反应性的相关关系。方法    对2009年10月至2010年5月在重庆医科大学附属儿童医院哮喘门诊就诊的273例哮喘患儿，测量肺功能并同时完成C-ACT评分，以第1秒用力呼气流量占预计值百分比（FEV1%）和最大呼气流量占预计值百分比（PEF%）作为通气功能指标与C-ACT进行相关性分析；根据乙酰甲胆碱激发实验将气道反应性分为重度、中度、轻度和极轻度4级，比较各级间C-ACT得分及大小气道通气功能指标的差异，研究C-ACT与通气功能及气道反应性的关系。结果    C-ACT与FEV1%、PEF%的相关系数分别为0.25和0.34（P＜0.01），去除就诊前4周患上呼吸道感染和小于7岁的患儿后，其相关系数分别为0.42和0.52 （P＜0.01）；气道反应性重度和极轻度组间C-ACT得分差异有统计学意义（P＜0.01），中度和轻度组间差异无统计学意义（P＞0.05）。结论    C-ACT评分与哮喘患儿通气功能、气道反应性有较好的相关性，就诊前4周内是否患有上呼吸道感染和年龄是影响其相关性的两个主要因素。

关键词: 哮喘, 儿童哮喘控制测试, 肺功能, 气道反应性