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CHEN Lu, FENG Qi.
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陈 璐,冯 琪
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Abstract: Objective To investigate vitamin A basic nutritional status, influencing factors and the efficacy of routine vitamin A supplement in premature infants. Methods Premature infants within 24 h of age were selected randomly to examine plasma retinol concentration. Full term infants worked as control. Premature infants received Vitamin A parenteral (1650 U/d) and/or enteral (750 U/d), and some of them were followed up about every 2 weeks. Plasma retinol level was detected by high-performance liquid chromatography (HPLC). Results One hundred and forty-seven premature infants and 40 full term infants were enrolled. Basic serum retinol levels in premature infant were lower than that in full term infants, (0.161±0.051)μg/mL and (0.187±0.055)μg/mL, t = 2.812, P = 0.005. Retinol level had positive relation with birth weight, β = 0.177, P = 0.015. The incidence of VAD (retinol level < 0.200 μg/mL) at birth was higher in premature infants, 78% vs 65%, χ2 = 2.623, P = 0.105. Thirty-one premature infants were followed up about 2 weeks later with enteral and/or parenteral nutrition. Significant increase of plasma retinol level and reduction of VAD incidence were noted, (0.168±0.046) μg/mL vs. (0.203±0.063)μg/mL, t = 2.611, P = 0.014; 100% vs. 48%, χ2 = 18.954, P < 0.001. No relation was showed between basic retinol levels, amount and method of vitamin A supplement with the follow-up levels. Basic retinol levels had no influence on clinical outcomes, such as infection, chronic lung disease and retinopathy of prematurity. Conclusion Premature infants have a poor vitamin A nutritional status and high incidence of VAD. Current routine vitamin A supplement has benefits to the improvement of its nutritional status in a short period.
Key words: routine supplement , vitamin A, retinol
摘要: 目的 评价早产儿基础维生素A营养状况、与疾病的关系及常规补充的效果。方法 高效液相色谱法检测2006年1月至2007年2月北京大学第一医院出生24 h 内的早产儿(147名)血浆视黄醇浓度,足月儿(40名)脐血作为对照。根据临床治疗常规,早产儿静脉(1650 U/d)和(或)口服(750 U/d)补充维生素A,随 访早产儿血浆视黄醇浓度。结果 出生时,早产儿血浆视黄醇浓度低于足月儿,差异有统计学意义,分别为(0.161±0.051)μg/mL 和 (0.187±0.055) μg/mL(P = 0.005)。早产儿维生素A 缺乏(VAD)发生率高于足月儿,但差异无统计学意义。多元线性回归分析显示出生体重与血浆视黄醇浓度呈正相关。31 例早产儿补充维生素A 2周后,随访血浆视黄醇浓度显著升高,分别为(0.168±0.046) μg/mL和 (0.203±0.063)μg/mL(P = 0.014);VAD发生率显著下降 ,分别为100%和48%(P < 0.001)。未发现补充剂量、方式对随访维生素A浓度的影响,未发现出生时血浆视黄醇浓度与新生儿期疾病的关系。结论 早产儿基础 维生素A营养状况不良,常规补充可在一定程度上改善2周时维生素A营养状况。
关键词: 早产儿, 维生素A, 视黄醇, 常规补充
CHEN Lu,FENG Qi.. Clinical study on vitamin A status and significance of supplement in premature infants.[J]. .
陈璐,冯琪. 早产儿维生素A营养不良及其补充治疗的临床研究[J]. 中国实用儿科杂志.
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