Abstract: AbstractObjectiveTo explored the risk factors of Gilles de la Tourette syndrome(TS). MethodsTotally 100 cases with TS and 100 controls were investigated through casecontrol study.Data was analyzed with nonconditional logistic regression and principal component analysis. ResultsResults from nonconditional logistic regression showed that such cases were associated with following factors:family history of TS,attention deficit hyperactivity disorder (ADHD),allergic asthma,nocuous mental stimulation during early pregnancy,high fever(T>39℃),exposure to pole low frequent electromagnetism field.The standard regression coefficients were 1.3987、3.6385、1.7657、1.7250、1.8973 and 1.0677，respectively.Four principal components were extracted through principal component analysis,and the cumulative contribution of variances of the 4 principal components was 57.025%. ConclusionThe risk factors of TS are related to the concomitance of genetic factors and environmental factors.

Key words: Principal component analysis , Risk factors, Nonconditional logistic regression

摘要： 目的探讨Tourette综合征(TS)发病的危险因素。 方法200001—200412采用病例对照研究的方法，对温州医学院附属一院100例TS患儿及100名对照病例的相关资料进行非条件Logistic回归和主成分分析。 结果非条件Logistic回归多因素分析显示，该病有统计学显著性意义的危险因素是TS家族史、注意缺陷伴多动障碍(ADHD)、过敏性哮喘、母亲孕早期受精神刺激、高热(T>39℃)和极低频磁场暴露，其标准回归系数分别为1.3987、3.6385、1.7657、1.7250、1.8973和1.0677。主成分分析提取了4个主成分，其方差累积贡献率为57.025%。 结论TS的发病与遗传因素和环境因素有关。

关键词: Tourette综合征, 危险因素, 非条件Logistic回归, 主成分分析