Abstract: AbstractObjectiveTo study the level of plasma ET1 and AngⅡ in child patients with obstructive sleep apneasyndrome and to discuss their clinical significance. MethodsEighty children patients with OSAS and 30 healthy children control were enrolled in the study;plasma ET1 and AngⅡ were measured. ResultsPlasma levels of ET1 and AngⅡ were significantly higher in patients with OSAS than those in control(P<0.05).There were negative correlations between the concentration of ET1 and the PSG in all the 80 children patients with OSAS.There were positive correlations between the concentration of AngⅡ and the lowest oxygen desaturation in all the 80 children patients with OSAS. ConclusionThese results indicate that the elevations of ET1 and AngⅡ in the children patients with OSAS may play an important role for the disease.

Key words: AngiotensionⅡ , Children, Endothelin1

摘要： 目的探讨儿童阻塞性睡眠呼吸暂停综合征(OSAS)患儿血浆内皮素1(ET1)和血管紧张素Ⅱ(AngⅡ)水平的变化及临床意义。 方法选择广州市2004年2月至2004年11月在儿童医院住院治疗的80例OSAS患儿及30例正常儿童，测定血浆ET1及AngⅡ水平。 结果与正常儿童相比，OSAS患儿血浆ET1及AngⅡ水平明显增高，差异有统计学意义(P<0.05)。ET1水平对多导睡眠图(PSG)结果无明显影响；AngⅡ浓度与最低SaO2相关。 结论血浆ET1和AngⅡ水平增加与OSAS发病有一定的关系。

关键词: 阻塞性睡眠呼吸暂停综合征, 儿童, 血浆内皮素1, 血管紧张素Ⅱ