Abstract: Abstract Objective To study the protective effect of highoxygen liquid on the brain in children with critical viral encephalitis. Methods Forty children with critical viral encephalitis were randomly divided into 2 groups:regular therapy group and highoxygen liquid group (regular therapy plus highoxygen liquid).The clinical symptoms and encephalogram were observed before and after therapy.The contents of endothelin (ET) and calcitonin gene related peptide (CGRP) in the cerebrospinal fluid (CSF) were detected by radioimmunoassay. Results Compared with regular therapy group,the time of hospitalization and disappearance of clinical symptoms and brain damage was shortened obviously(^P<0.05 or 0.01); ET、ET/CGRP decreased remarkably and CGRP was statistically higher in highoxygen liquid group (^P<0.05 or 0.01). Conclusion1.The imbalance of ET/CGRP in CSF is an important factor to the occurrence and development in viral encephalitis.2.The highoxygen liquid has protective effect on the brain of children with critical viral encephalitis,through ameliorating oxygensupply and restoring the balance of ET/CGRP in CSF.

Key words: Viral encephalitis , Endothelin, Calcitonin gene related peptide

摘要： 目的 探讨高氧液对病毒性脑炎患儿脑组织保护作用的机制。 方法 以2004年1~12月武汉市儿童医院收治的40例病毒性脑炎患儿为研究对象，随机分为常规治疗组和高氧液治疗组(常规治疗+高氧液)，治疗前后观察临床症状及脑影像学改善情况，并采用放射免疫法监测脑脊液内皮素(ET)和降钙素基因相关肽(CGRP)质量浓度变化。 结果 与常规组比较，高氧液组临床症状和脑影像学改变的消失时间以及住院时间明显缩短(^P<0.05，^P<0.01)；ET、ET/CGRP比值降低和CGRP升高更为显著(^P<0.05，^P<0.01)。 结论 ①ET/CGRP比值失衡是导致病毒性脑炎发生、发展的重要因素；②高氧液通过改善脑组织供氧、恢复ET/CGRP动态平衡，从而发挥其保护作用。

关键词: 高氧液, 内皮素, 降钙素基因相关肽, 病毒性脑炎