Abstract: Epstein-Barr virus （EBV） is a B-cell-tropic double-stranded DNA virus belonging to the gamma herpesvirus family， characterized by high susceptibility and predominantly transmitted through bodily fluids. Primary EBV infection typically targets the epithelial cells of the oropharynx and nasopharynx，with a propensity for long-term latency in lymphoid tissues. Primary EBV infections are common in children and often involve many systems, leading to a variety of effects on multiple organs. The effect of EBV infection on digestive system of children is gaining more and more attention， and EBV is closely related to digestive diseases including liver， gastrointestinal tract， pancreas and cholecyst， etc. Its pathogenesis often involves immune inflammatory reactions， but there is still a lack of large sample, multicenter research.

Key words: Epstein-Barr virus, child, digestive diseases, liver function injury, gastrointestinal disorders

摘要： EB 病毒（Epstein-Barr virus，EBV）是一种嗜 B 细胞的双链 DNA 病毒，隶属 γ 型人类疱疹病毒，具有高度易感性，主要通过体液传播。其初次感染多发生于口咽和鼻咽上皮细胞，并可长期潜伏于淋巴组织中。EBV 原发感染在儿科人群中较为常见，可累及多个系统并对多个器官产生多样性影响。EBV 感染对儿童消化系统的影响越来越受到关注，EBV 与肝脏、胃肠道、胰腺、胆囊等消化系统疾病关系密切，其发病机制多涉及免疫炎症反应，但仍缺乏大样本、多中心研究。

关键词: EB 病毒, 儿童, 消化道疾病, 肝功能损伤, 胃肠道疾病