关键词: 小麦依赖 - 运动诱发严重过敏反应, 儿童, 皮肤点刺试验, 特异性 IgE, 口服食物激发试验

Abstract: Wheat-dependent，exercise-induced anaphylaxis（WDEIA）is an immunoglobulin E（IgE）-mediated disease which is characterized by systemic allergic reactions triggered by synergistic factors such as exercise after wheat ingestion.It is characterized by sudden onset，high risk，and easy misdiagnosis.The clinical manifestations mainly involve the skin and respiratory and cardiovascular systems.In older children，severe cases are more common，but due to non-specific symptoms，it is often misdiagnosed.Accurate diagnosis depends on a detailed medical history，skin prick tests（especially fresh food prick tests），specific IgE（sIgE）detection，and confirmation by exercise-food combined challenge tests when necessary.The management of WDEIA in acute stage focuses on the timely use of adrenaline，while long-term strategies include avoiding high-risk factors，individualized dietary adjustments，and exploring immunotherapy，such as omalizumab and sublingual immunotherapy.Given the particularities of children’s behavior and lifestyle，the collaborative management involving families，schools，and medical teams is crucial for preventing attacks and improving the quality of life.In the future，further promotion of standardized diagnostic procedures and long-term intervention studies is needed to achieve precise prevention and control of WDEIA in children.

Key words: wheat-dependent, exercise-induced anaphylaxis, child, skin prick test, specific IgE, oral food challenge test