中国实用儿科杂志

中国实用儿科杂志 ›› 2023, Vol. 38 ›› Issue (5): 356-359.DOI: 10.19538/j.ek2023050608

• 专题笔谈 • 上一篇    下一篇

新生儿脓毒症相关脑损伤的临床特点与发生机制

  

  1. 国家儿童健康与疾病临床医学研究中心  儿童发育疾病研究教育部重点实验室  儿童感染免疫重庆市重点实验室  重庆医科大学附属儿童医院新生儿科，重庆  400013
  • 出版日期:2023-05-06 发布日期:2023-06-12
  • 通讯作者: 史源，电子信箱：shiyuan@hospital.cqmu.eu.cn
  • 基金资助:
    国家重点研发计划（2022YFC2704803）

Clinical characteristics and pathogenesis of brain injury associated with neonatal sepsis

  1. National Clinical Research Center for Child Health and Disorders；Ministry of Education Key Laboratory of Child Development and Disorders；Chongqing Key Laboratory of Child Infection and Immunity；Department of Neonatology，Children’s Hospital of Chongqing Medical University，Chongqing  400013，China
  • Online:2023-05-06 Published:2023-06-12

摘要： 新生儿脓毒症可能增加新生儿脑损伤和神经认知长期不良预后的风险。血脑屏障功能障碍以及炎症因子、细胞毒性、氧自由基等介导的炎症损伤是新生儿脓毒症相关脑损伤的重要发病机制。新生儿科医师应重视新生儿脓毒症相关脑损伤，在积极有效抗感染治疗的同时，密切随访新生儿神经系统发育情况。该文就新生儿脓毒症相关脑损伤的临床特点和发生机制进行概述，以期为临床干预提供依据。

关键词: 新生儿, 脓毒症, 临床特点

Abstract: Neonatal sepsis might increase the risk of brain injury and long-term poor prognosis. The dysfunction of blood-brain barrier and the inflammation caused by cytotoxicity，proinflammatory factor and oxygen radicals may contribute to the pathogenesis of neonatal sepsis-related brain injury. The neonatologists should pay attention to the neonatal sepsis related brain injury，and apart from anti-infection treatment，the follow- up of the development of central nervous system should also be made. This commentary just briefly summarizes the characteristics and pathogenesis of neonatal sepsis-related brain injury，aiming to provide evidence for the future intervention.

Key words: newborn, sepsis, clinical features