中国实用儿科杂志

中国实用儿科杂志 ›› 2022, Vol. 37 ›› Issue (9): 660-663.DOI: 10.19538/j.ek2022090604

• “一切为了人民健康———我们这十年”专栏·专题笔谈 • 上一篇    下一篇

上-下气道疾病联合管理的生理和免疫基础

  

  1. 1.四川大学华西第二医院小儿呼吸免疫科  出生缺陷与相关妇儿疾病教育部重点实验室  国家卫生健康委员会时间生物学重点实验室（四川大学），四川  成都  610041；２.成都大学附属医院，四川  成都  610081
  • 出版日期:2022-09-06 发布日期:2022-09-27
  • 通讯作者: 陈莉娜，电子信箱：chenln66@163.com
  • 基金资助:
    四川省重大科技专项（22ZDZX0014）；四川大学华西第二医院临床科研基金（KL036）及学科发展基金（KL118）

Physiological and immunological basis of joint management of upper and lower airway diseases

  1. *Division of Pediatric Pulmonology and Immunology， West China Second University Hospital， Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children （Sichuan University）， Ministry of Education; NHC Key Laboratory of Chronobiology （Sichuan University） ， Chengdu 610041， China
  • Online:2022-09-06 Published:2022-09-27

摘要： 上-下气道疾病在流行病学、病理生理、临床表现、治疗策略等方面存在不同程度关联。该文总结了上-下气道的解剖、生理和免疫基础的异同，并以过敏性鼻炎及支气管哮喘为例比较了上-下气道疾病发病机制的异同及联系，以期为临床医生更好理解“同一气道，同一疾病”联合管理提供理论依据。

关键词: 上气道, 下气道, 疾病, 炎症, 生理, 免疫, 机制

Abstract: Upper and lower airway diseases are related in epidemiology， pathophysiology， clinical manifestations and treatment strategies to varying degrees. This article reviews the similarities and differences in anatomical， physiological and immune basis of upper and lower airways， and compares the differences and similarities in pathogenesis and connection of upper and lower airway diseases by taking allergic rhinitis and bronchial asthma as examples， hoping to provide a theoretical basis for clinicians to better understand the joint management of “one airway， one disease”.

Key words: upper airway, lower airway, diseases, inflammation, physiology, immunology,  , mechanisms