中国实用儿科杂志

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儿童暴发性肝衰竭血液净化疗法

王墨李秋   

  1. 作者单位: 重庆医科大学附属儿童医院血液净化中心, 重庆 400014
  • 出版日期:2014-03-06 发布日期:2014-03-11

Blood purification therapy for fulminant hepatic failure in children.

WANG Mo , LI Qiu.   

  1. Blood Purification Center of Children’s Hospital of Chongqing Medical University,Chongqing  400014, China
  • Online:2014-03-06 Published:2014-03-11

摘要:

小儿暴发性肝衰竭病情危重,病死率高。血液净化技术作为最常使用的非生物型人工肝装置,在帮助患儿渡过肝衰竭危险期、等待肝细胞再生或维持生存至得到供体进行肝移植方面起着极为有效的作用。人工肝应用至今已逾50年,在常用血浆置换、血液灌流、血液透析滤过等多种方式的基础上,新型的净化模式已在临床广泛应用,并取得了很好的疗效,成为治疗暴发性肝衰竭的重要治疗手段之一。人工肝在儿科临床也有应用报道,但多中心的研究资料有限,仍需要进一步研究和实践。

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关键词: 儿童, 暴发性肝衰竭, 血液净化, 治疗

Abstract:

Children with fulminant hepatic failure are in critical condition and high mortality. Blood purification technology as the most frequently used devices of non-biological artificial liver plays an effective role in helping children through the liver failure risk, liver cell regeneration and survive to liver transplantation. Artificial liver has been used for more than 50 years. New blood purification models which based on plasma exchange, hemoperfusion, hemodiafiltration andother methods have been widely used in clinical practice and become one of the important therapies for fulminant hepatic failure. Artificial liver has been used in children, but multi-center studies are needed.

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