中国实用儿科杂志

中国实用儿科杂志 ›› 2011, Vol. 26 ›› Issue (05): 369-.

• 论著 • 上一篇    下一篇

儿童胰腺假乳头状肿瘤临床特征分析

  

  1. 郑州大学第一附属医院小儿外科，河南省高等学校临床医学重点学科开放实验室，郑州　450052
  • 收稿日期:2010-12-25 修回日期:2010-03-11 出版日期:2011-05-06 发布日期:2011-07-05

Different clinical feature analysis of solid-pseudopapillary tumor of pancreas between children and adults.　　

  1. The First Affiliated Hospital of Zhengzhou University，Zhengzhou 450052，China
  • Received:2010-12-25 Revised:2010-03-11 Online:2011-05-06 Published:2011-07-05

摘要：

分析儿童和成人胰腺假乳头状肿瘤的临床特点，寻找有恶性潜能的临床特征。方法　2010年10月检索中国万方全文数据库，根据建立的纳入和排除标准，对符合标准的386例和我院2006年1月至2010年6月收治的10例患者的临床资料进行回顾性分析。结果　396例患者中，儿童45例，成人351例。儿童多因扪及腹部包块（46.7%）和腹痛（31.1%）而发现，而成人多是因体检（37.9%）和腹部不适（27.4%）发现。儿童肿块的平均直径较成人大（P < 0.05）。儿童肿瘤多位于胰腺头颈部（57.8%），而成人多位于体尾部65.2%）。单因素变量分析表明门静脉浸润（P < 0.01）和肿瘤远处转移（P < 0.01）在儿童和成人SPTP良恶性方面的差异均有统计学意义。结论　成人和儿童的SPTP有不同的临床特征，门静脉浸润和远处转移可能是潜在的恶性表现，手术完整切除肿瘤并长期随访是较好的治疗策略。

关键词: 胰腺假乳头状肿瘤, 儿童, 成人, 临床特征

Abstract:

To analyze the clinical features of solid-pseudopapillary tumor of pancreas （SPTP） between children and adults，and determine the predictive features of malignant potential. Methods　Besides 10 patients we received from January 2006 to June 2010，386 patients were collected by retrieveing China Wanfang Data during October 2010，and all the information was analyzed retrospectively. Results 　Among 396 patients，45 patients were children and 351 patients were adults. A palpable mass （46.7%） and abdominal pain （31.1%） were the most common presenting symptom in children，while in adults，the tumor was always found by health examination （37.9%） or abdominal discomfort （27.4%）. The mean tumor size in children was larger than in adults（P < 0.05）. In children，the tumor was located in the head or neck of the pancreas （57.8%），while in adults，in the body or tail （65.2%） （P = 0.003）. Univariate analysis indicated that the difference of portal vein invasion and metastasis between benign and malignant of SPTP was significant both in children and adults. Conclusion　SPTP has different clinical features in children and adults. Portal vein invasion and metastasis are probably the potential malignant presentations. Complete removal and long term follow-up are the best choice.

Key words: solid-pseudopapillary tumor of pancreas, children, adults, clinical feature