中国实用儿科杂志

中国实用儿科杂志 ›› 2025, Vol. 40 ›› Issue (7): 582-585.DOI: 10.19538/j.ek2025070611

• 论著 • 上一篇    下一篇

儿童自身免疫性胰腺炎 5 例临床分析

  

  1. 国家儿童医学中心（北京）  首都医科大学附属北京儿童医院消化科，北京  100045
  • 出版日期:2025-07-06 发布日期:2025-09-02
  • 通讯作者: 吴捷，电子信箱：wujie@bch.com.cn
  • 基金资助:
    北京市医院管理中心“ 登峰”人才培养计划（DFL20221003）

Clinical analysis of 5 child patients with autoimmune pancreatitis

  1. Department of Gastroenterology，Beijing Children’s Hospital，Capital Medical University/National Center for Children’s Health，Beijing  100045，China
  • Online:2025-07-06 Published:2025-09-02

摘要：

目的 探讨儿童自身免疫性胰腺炎（AIP）临床特征与转归，为临床诊治提供思路。方法　回顾性分析2020年7月至2024年1月首都医科大学附属北京儿童医院诊断的5例 AIP 患儿临床资料，分析其临床症状、治疗方法和随访结果。结果 5例中2例为2型 AIP，2例未明确分型，1例3型 AIP。其中男4例、女1例，平均年龄为（10.87±3.86）岁。临床表现主要为腹痛4例，黄疸3例。5例患儿血清 IgG4水平正常。所有患儿均有典型影像学表现，胰腺局灶性增大4例、胰腺弥漫性增大1例，其中1例同时合并胰腺局灶肿物。1例患儿进行了病理活检提示胰腺导管周围淋巴细胞浸润、胰腺间质炎性改变。5例患儿接受激素治疗后均获得临床及影像学缓解，随诊均未见复发。结论 儿童 AIP 发病率低，临床特征不明显，激素治疗效果明显；充分认识儿童 AIP 的临床特征有助于早期识别 AIP、避免漏诊及误诊。

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Abstract:

Objective To explore the clinical characteristics and outcomes of autoimmune pancreatitis（AIP）in children， and to provide ideas for clinical diagnosis and treatment. Methods Clinical data of 5 children diagnosed with AIP at Beijing Children’s Hospital from July 2020 to January 2024 were retrospectively analyzed.The clinical symptoms，treatment methods and follow-up results were analyzed. Results Among the 5 children with AIP ， there were 2 cases of type 2 AIP，2 cases were not specified and 1 case might be type 3 AIP.There were 4 boys and 1 girl，with an average age of（10.87±3.86）years.The main clinical manifestations were abdominal pain（4 cases）and jaundice（3 cases）. All patients had normal serum IgG4 levels.All children had typical imaging manifestations，including focal pancreatic enlargement in 4 cases and diffuse pancreatic enlargement in 1 case，with 1 case also having a focal pancreatic mass. One child underwent a pathological biopsy，which showed periductal lymphocyte infiltration and interstitial inflammatory changes in the pancreas.All 5 children achieved clinical and imaging remission after hormone treatment. No recurrence was observed during follow-up. Conclusion The incidence of AIP in children is low， the clinical features are not obvious， and the hormone therapy has significant effect. A full understanding of the clinical features of AIP in children is helpful for early identification of AIP and avoiding missed diagnosis and misdiagnosis.

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