中国实用儿科杂志

中国实用儿科杂志 ›› 2025, Vol. 40 ›› Issue (10): 837-841.DOI: 10.19538/j.ek2025100609

• 专题笔谈 • 上一篇    下一篇

儿童热性感染相关性癫痫综合征的诊治

  

  1. 西安交通大学附属儿童医院儿童重症医学科，陕西  西安  710003
  • 出版日期:2025-10-06 发布日期:2025-11-12
  • 通讯作者: 王义，电子信箱：wangyichengxian@163.com
  • 基金资助:
    西安市科技局西安市创新能力强基计划医学研究项目（22YXYJ0084，21YXYJ0009）；西安市儿童医院一般项目扶持项目（2021G12）；西安市儿童医院重点项目 - 医联体项目（2024A02）

Progress in the diagnosis and treatment of febrile infection-related epilepsy syndrome in children

  1. Pediatric Intensive Care Unit，The Affiliated Children’s Hospital of Xi’an Jiaotong University，Xi’an  710003，China
  • Online:2025-10-06 Published:2025-11-12

摘要：

热性感染相关性癫痫综合征（febrile infection-related epilepsy syndrome，FIRES）是新发难治性癫痫持续状态（new-onset refractory status epilepticus，NORSE）的一种亚型，其特征为难治性癫痫持续状态，预后差，可遗留严重认知行为功能障碍和药物难治性癫痫等。近年来随着对该病认识的加深，治疗理念也有所转变，提倡在规范抗癫痫发作治疗的基础上，早期及时免疫治疗和综合支持。文章从FIRES 的发病机制、临床表现、治疗及预后方面进行了阐述，以期提高认识，改善预后。

关键词:

Abstract: Febrile infection-related epilepsy syndrome（FIRES） is a subtype of new-onset refractory status epilepticus（NORSE），characterized by refractory status epilepticus and poor prognosis，and may leave behind severe cognitive andbehavioral dysfunction and drug-resistant epilepsy，etc. In recent years，with the deepening of understanding of this disease，the treatment concept has also changed. It is advocated that on the basis of standardized anti-epileptic seizure treatment，early and timely immunotherapy and comprehensive support should be carried out. This article elaborates on the pathogenesis，clinical manifestations，treatment and prognosis of FIRES，with the aim of enhancing understanding and improving prognosis.

Key words: