中国实用儿科杂志

中国实用儿科杂志

• 专题笔谈 • 上一篇    下一篇

蛋白尿的发生机制研究进展

  

  1. 华中科技大学同济医学院附属同济医院儿科，湖北  武汉  430030
  • 出版日期:2016-11-06 发布日期:2016-11-09

Progress in study of proteinuria mechanism

  1. Department of Pediatrics，Tongji Hospital，Tongji Medical College，Huazhong University of Science & Technology， Wuhan  430030， China
  • Online:2016-11-06 Published:2016-11-09

摘要：

蛋白尿的主要发生机制是肾小球滤过增加和（或）肾小管重吸收障碍。近年来，对肾小球滤过屏障研究取得显著进展，内皮细胞表层和足细胞下间隙成为肾小球滤过屏障新组分，发现越来越多的足细胞分子与蛋白尿关系密切，主导或者参与了肾小球疾病的发生。

关键词: 蛋白尿, 机制, 肾小球滤过屏障, 足细胞

Abstract:

Proteinuria occurs mainly due to increased filtration of plasma proteins through glomerular capillary wall and/or incapability of renal tubular reabsorption of small molecular proteins. Significant advances have been made in study on glomerular filtration barrier in recent years. Now endothelial surface layer and subpodocyte space have been accepted as new layers of whole glomerular filtration barrier，and more and more podocyte molecules   have been found to play a causative role or participate in the occurrence of proteinuria.

Key words: proteinuria, mechanism, glomerular filtration barrier, podocyte