关键词: 乳糜泻, 流行病学, 发病机制, 临床表现, 诊断, 管理, 儿童

Abstract: Celiac disease，also known as gluten sensitive enteropathy，is an immune-mediated intestinal inflammation in genetically susceptible population，which can also cause systemic diseases. The initial diagnosis is serological test under the condition of gluten diet，and the positive patients are further confirmed by gastroscopic histopathological examination. In 2020，the European Society for Pediatric Gastroenterology，Hepatology and Nutrition（ESPGHAN） revised the diagnostic process of celiac disease again，and continued to agree with the no-biopsy diagnosis criteria proposed by ESPGHAN in 2012. The diagnosed patients need to eat gluten-free diet for life，which can make the symptoms of most patients completely subside and mucosal healing.

Key words: celiac disease, epidemiology, pathogenesis, clinical manifestations, diagnosis, management, child