中国实用儿科杂志

中国实用儿科杂志 ›› 2026, Vol. 41 ›› Issue (5): 415-421.DOI: 10.19538/j.ek2026050612

• 论著 • 上一篇    下一篇

食物过敏儿童血浆趋化因子CCL22的表达及意义

  

  1. 1.南方医科大学附属广东省人民医院（广东省医学科学院）儿科，广东  广州  510080；2.广州市荔湾中心医院儿科，广东  广州  510170
  • 出版日期:2026-05-06 发布日期:2026-06-25
  • 通讯作者: 杨敏，电子信箱：yangmin1008@gdph.org.cn

Expression and significance of chemokine CCL22 in children with food allergy

  1. Department of Pediatrics，Guangdong Provincial People’s Hospital，Guang dong Academy of Medical Sciences，Southern Medical University，Guangzhou  510080，China
  • Online:2026-05-06 Published:2026-06-25

摘要： 目的　检测食物过敏儿童的血常规、血清总IgE、食物特异性IgE（sIgE）及血浆趋化因子CCL22水平，探讨上述指标在IgE介导与非IgE介导型食物过敏中的临床意义。方法　选取2023年8月至2024年4月在广东省人民医院临床确诊为食物过敏的0～18岁儿童，检测血常规、血清总IgE、食物过敏原sIgE、血浆趋化因子CCL22的表达水平。根据食物sIgE检测结果分为IgE阳性组（sIgE≥0.35 kU/L）和IgE阴性组（sIgE<0.35 kU/L），根据年龄分为婴儿组、幼儿组、学龄前期组、学龄期组及青春期组，分析IgE阳性组与阴性组及不同年龄组的血常规各项指标、总IgE、食物sIgE及CCL22表达水平的差异。采用Spearman等级相关分析探索年龄、趋化因子CCL22水平、血清总IgE、sIgE及血常规指标间的相关性。结果　总计纳入199例食物过敏儿童，其中男性115例（57.8%），女性84例（42.2%）。年龄范围4月龄~15岁，中位年龄为3.9（1.3，7.3）岁。血清总IgE增高106例（53.3%），食物过敏原血清sIgE阴性110例（55.3%），sIgE阳性89例，8种常见过敏性食物中，仅1种食物sIgE阳性40例（20.1%），2种食物sIgE阳性32例（16.1%），3种及以上食物sIgE阳性17例（8.5%）。血浆CCL22水平与外周血淋巴细胞计数、淋巴细胞百分比和牛奶sIgE水平呈正相关，而与中性粒细胞计数、中性粒细胞百分比、总IgE及蟹和虾sIgE水平呈负相关；总IgE水平的总体趋势随年龄的增大而增高；在8大类过敏性食物中，幼儿组在鸡蛋白、牛奶、小麦和芝麻sIgE水平均高于其他年龄组，差异有统计学意义（均P<0.05）。结论　血常规中的嗜酸性粒细胞和中性粒细胞指标有助于区分IgE和非IgE介导的食物过敏，总IgE及食物sIgE水平有年龄特异性。血浆CCL22与特定过敏原和免疫细胞类型有关，可为理解食物过敏的免疫机制提供新线索。临床实践中，联合检测血常规、总IgE和sIgE可为食物过敏分型提供参考。

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Abstract: Objective　To determine the complete blood count，serum total IgE levels，food-specific IgE（sIgE），and plasma chemokine CCL22 concentrations in children diagnosed with food allergies，and to explore the clinical significance of these indicators in both IgE-mediated and non-IgE-mediated food allergies. Methods　The children aged 0～18 years who were clinically diagnosed with food allergies at Guangdong Provincial People's Hospital between August 2023 and April 2024 were selected for this study.　Measurements included complete blood count，and the expression levels of serum total IgE，sIgE specific to various food allergens，and plasma CCL22. Based on the results of sIgE，participants were categorized into an IgE positive group（sIgE≥0.35 kU/L）and an IgE negative group（sIgE<0.35 kU/L）. Furthermore，subjects were divided into five age groups：infants，toddlers，preschoolers，school-aged children，and adolescents. Differences in complete blood count parameters，total IgE levels，sIgE related to specific foods，and CCL22 expression between the two main groups as well as among different age groups were analyzed. Spearman rank correlation analysis was employed to investigate correlations among age，CCL22 levels，serum total IgE concentrations，sIgEs for specific foods，and complete blood count parameters. Results　A total of 199 children with food allergies were included in the study，including 115 males（57.8%）and 84 females（42.2%）. The age range of participants varied from 4 months to 15 years，with a median age of 3.9（1.3，7.3）years. There were 106 cases（53.3%）exhibiting elevated total serum IgE levels，110 cases（55.3%）with negative serum sIgE for food allergens and 89 cases with positive sIgE. Among the 8 common allergenic foods，40 cases（20.1%） were positive for sIgE in only one kind of food，32 cases（16.1%）were positive for sIgE in two kinds of food，and 17 cases（8.5%）were positive for sIgE in three or more kinds of food. The level of plasma CCL22 was positively correlated with the count of peripheral blood lymphocytes，the percentage of lymphocytes and the sIgE level in milk，but negatively correlated with the count of neutrophils，the percentage of neutrophils，total IgE and the sIgE level in crabs and shrimps. The overall trend of total IgE levels increased with age. Among the eight major types of allergenic foods，the sIgE levels in egg white，milk，wheat and sesame in the infant group were all higher than those in other age groups，and the differences were significant（all P<0.05）. Conclusion　The eosinophils and neutrophils in the blood routine are helpful in distinguishing IgE-mediated from non-IgE-mediated food allergies. The levels of total IgE and food sIgE are age-specific. Plasma CCL22 is associated with specific allergens and immune cell types，which can provide new clues for understanding the immune mechanism of food allergies. In clinical practice，the combined detection of blood routine，total IgE and sIgE can provide a reference for the classification of food allergies.

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