关键词: 先天性甲状腺功能减退症, 新生儿疾病筛查, 促甲状腺激素

Abstract: Objective    To study the epidemiological characteristics and risk factors of congenital hypothyroidism（CH） in Xi'an，and to provide evidence for making intervention strategies. Methods    From January 1，2020 to December 31，2021，the screening data for neonatal CH at the Xi'an Neonatal Disease Screening Center were gathered. The case group and the control group's fundamental data，clinical characteristics，and other related data were analyzed using univariate analysis by the case-control study technique. From the univariate analysis，a few factors that were statistically different were chosen and were inclucled in the multivariate Logistic regression equation analysis. Results    Between 2020 and 2021，148250 newborns were screened for CH；104 of them were found to have the disease. Multiple Logistic regression analysis revealed that long period of pregnancy，high educational level of mothers， and birth weight being 2.5~4 kg were protective factors of CH（P<0.05）, while the risk factors were birth season being winter，maternal thyroid diseases during pregnancy，mother's advancedage，multiple pregnanay or delivery and cesarean section. Conclution    The incidence rate of CH in Xi'an is basically the same as that in China's iodine-sufficient regions. The CH screening rate in Xi'an has steadily increased in recent years. It is advised that women of childbearing age get ready for pregnancy and receive prenatal care to improve population quality since maternal personal variables and environmental factors affect the etiology of neonatal CH.

Key words: congenital hypothyroidism, neonatal disease screening, thyroid stimulating hormone