关键词: 婴儿, 百日咳脑病, 惊厥发作, 爆发抑制

Abstract: The data of 2 children with pertussis encephalopathy admitted to Wuhan Children's Hospital，Tongji Medical College，Huazhong University of Science and Technology from September 2022 to October 2022 were retrospectively analyzed，and their clinical characteristics，diagnosis and treatment methods were summarized. It is found that the onset age of the 2 children with pertussis encephalopathy was within 3 months，and 1 of them had a history of contact with patients with cough，and no infection lesions were found in brain MRI.The convulsive seizures of the 2 children occurred at 2-3 weeks in the course of the disease，and the outbreak inhibition of EEG was present at 5-7 weeks in the course of the disease.In case 1，the EEG condition could be improved after the use of topax + levetiracetam. In case 2，the electroencephalogram was finally improved by the combination of topac and valproic acid. The literature analysis shows that pertussis encephalopathy is more common in infants of small months who have not received pertussis vaccine，most of which are caused by contact with coughing family members，and convulsive seizures are not correlated with EEG changes. This paper shows that topathy can effectively control seizures，and at the same time，by combination with other anti-seizure drugs EEG improvement is achieved.

Key words: baby, pertussis encephalopathy, convulsive seizure, burst suppression